Chemistry of Ecteinascidins. Part 2. Preparation of 6'-O-Acyl Derivatives of Stable Ecteinascidin and Evaluation of Cytotoxicity

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概要

• 論文の詳細を見る

• A large amount of stable ecteinascidin 770 (1b) was isolated from the Thai tunicate, Ecteinascidia thurstoni, which was pretreated with potassium cyanide in buffer solution (pH 7), along with a minor metabolite, ecteinascidin 786 (1c). A number of 6'-O-acyl derivatives 3-19 and three diacetyl derivatives 2a-c of the stable 1b were prepared and evaluated for activity against human tumor cell lines HCT116, QG56, and DU145. Nitrogen-containing heterocyclic ester derivatives such as 12, 13, and 16-19 showed similar in vitro cytotoxicity to 1b, whereas the other derivatives were less cytotoxic than 1b. Furthermore, we discovered that the N-indole-3-carbonyl derivative of ecteinascidin 770 (22) has higher cytotoxicity than 1b.

• 社団法人日本薬学会の論文
• 2006-07-01

著者

• 久保 陽徳

  明治薬科大学

• Suwanborirux Khanit

  Bioactive Marine Natural Products Chemistry Research Unit, Faculty of Pharmaceutical Sciences, Chula

• Saito Naoki

  Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University

• AMNUOYPOL Surattana

  Bioactive Marine Natural Products Chemistry Research Unit (BMNCU), Department of Pharmacognosy, Facu

• PUTHONGKING Ploenthip

  Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University

• PATARAPANICH Chamnan

  Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University

• KUBO Akinori

  Faculty of Pharmaceutical Sciences, Meiji Pharmaceutical University

• SAITO Naoki

  Faculty of Pharmaceutical Sciences, Meiji Pharmaceutical University

• Suwanborirux Khanit

  Bioactive Marine Natural Products Chemistry Research Unit (bmncu) Department Of Pharmacognosy Facult

• Suwanborirux Khanit

  Bioactive Marine Natural Products Chemistry Research Unit (bmncu) Department Of Pharmacognosy

• Kubo Akinori

  Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University

• Amnuoypol Surattana

  Bioactive Marine Natural Products Chemistry Research Unit (bmncu) Department Of Pharmacognosy Facult

• Patarapanich Chamnan

  Department Of Pharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Chulalongkorn University

• Puthongking Ploenthip

  Department Of Pharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Chulalongkorn University

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