Jorunnamycins A-C, New Stabilized Renieramycin-Type Bistetrahydroisoquinolines Isolated from the Thai Nudibranch Jorunna funebris

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概要

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• Jorunnamycins A-C (1a-c), three stabilized renieramycin-type bistetrahydroisoquinolines, were isolated from the mantles, the visceral organs, and the egg ribbons of the Thai nudibranch Jorunnafunebris that was pretreated with potassium cyanide (KCN), along with five known compounds, renieramycins M (2m), N (2n), O (2o), and Q (2q) and mimosamycin (3). The structures of 1a-c were elucidated from spectroscopic data and by chemical conversion of renieramycin M (2m) into 1c via 1a. The chemical stability and the oxidative degradation generating simple isoquinoline alkaloids of a carbinolamine analog 1d, which was easily prepared by reacting 1c with silver nitrate in aqueous acetonitrile, are discussed. The results of cytotoxicity studies are also presented.

• 2007-01-01

著者

• 久保 陽徳

  明治薬科大学

• Suwanborirux Khanit

  Bioactive Marine Natural Products Chemistry Research Unit, Faculty of Pharmaceutical Sciences, Chula

• Saito Naoki

  Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University

• CHARUPANT Kornvika

  Bioactive Marine Natural Products Chemistry Research Unit (BMNCU), Department of Pharmacognosy, Facu

• AMNUOYPOL Surattana

  Bioactive Marine Natural Products Chemistry Research Unit (BMNCU), Department of Pharmacognosy, Facu

• SAITO Emi

  Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University

• KUBO Akinori

  Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University

• Suwanborirux Khanit

  Bioactive Marine Natural Products Chemistry Research Unit (bmncu) Department Of Pharmacognosy Facult

• Suwanborirux Khanit

  Bioactive Marine Natural Products Chemistry Research Unit (bmncu) Department Of Pharmacognosy

• Kubo Akinori

  Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University

• Saito Emi

  Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University

• Saito Naoki

  Graduate School Of Natural Science And Technology Okayama University

• Charupant Kornvika

  Bioactive Marine Natural Products Chemistry Research Unit (bmncu) Department Of Pharmacognosy Facult

• Amnuoypol Surattana

  Bioactive Marine Natural Products Chemistry Research Unit (bmncu) Department Of Pharmacognosy Facult

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