Synthesis of Renieramycins: Construction of the Core Ring System of Cribrostatin 4 through Modified Pictet–Spengler Cyclization of 3,6-Bisarylpiperazine-2,5-dione with Diethoxyethyl Benzoate
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概要
- 論文の詳細を見る
A nine-step synthesis of pentacyclic key intermediate 11 of cribrostatin 4 (2) along with renieramycin I (1i) from 3,6-bisarylpiperazine-2,5-dione derivative 3 is described. The key step of this synthesis is the stereoselective cyclization of lactam nitrogen with diethoxyethyl benzoate, followed by the stereoselective hydrogenation to generate ABC ring system 6.
- 公益社団法人 日本薬学会の論文
著者
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YOKOYA Masashi
Graduate School of Pharmaceutical Sciences, Chiba University
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Saito Naoki
Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University
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ITO Hiroshi
Graduate School of Materials Science, Nara Institute of Science and Technology
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Saito Naoki
Graduate School Of Natural Science And Technology Okayama University
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Yokoya Masashi
Graduate School Of Pharmaceutical Sciences Chiba University
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SAITO Naoki
Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University
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Yokoya Masashi
Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University
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