Gardneria Alkaloids(第5報) : Sarpagine骨核のC, D環開裂反応
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概要
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The C, D ring cleavage reactions were studied on the Nb-methiodides of several compounds bearing the sarpagine skeleton, namely gardnerine (I), deoxyajmalol-B (II) and Na-demethyldeoxyajmalol-B (III). By reduction with sodium in liquid ammonia, I-methiodide (IV) afforded the C, D ring open compound (VI) in low yield probably because of the presence of the ethylidene side chain. On the other hand, II-methiodide (X) afforded the desired compound (XI) in a yield of 50-65%. By reduction with LiAlH_4,IV gave various product snamely VII, VIII, V, but failed to give VI.
- 公益社団法人日本薬学会の論文
- 1970-02-25
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