Effects of Acute Administration of Nicotine on Convulsive Movements and Blood Levels of Corticosterone in Old Rats.
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概要
- 論文の詳細を見る
The convulsive movements, blood levels of corticosterone and pharmacokinetics of nicotine after an acute intraperitoneal injection of nicotine (5 mg/kg) were examined in young (6-week-old) and old (2-year-old) rats. In pharmacokinetic study, blood nicotine levels during the elimination phase were significantly higher in old rats than in young rats. However, the duration of convulsions and the elevation of corticosterone levels after the nicotine injection showed significant decreases in old rats compared with those in young rats. These differences of nicotine-induced responses between young and old rats may be involved in the decrease in nicotine sensitivity.
- 公益社団法人 日本薬理学会の論文
著者
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Kita Taizo
Department Of Pharmacology Daiichi College Of Pharmaceutical Sciences
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Okuda Hirotsugu
Department Of Internal Medicine National Insurrance Union Medical Center Of Nara
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Nakashima Toshikatsu
Department Of Pharmacology Nara Medical College
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Tanaka Takeshi
Department Of Biomedical Chemistry Graduate School Of Medicine The University Of Tokyo
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Tanaka Takeshi
Department of Pharmacology, Nara Medical University
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Okamoto Masato
Department of Pharmacology, Nara Medical University
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