Effect of Nicotine-Induced Corticosterone Elevation on Nitric Oxide Production in the Passive Skin Arthus Reaction in Rats
スポンサーリンク
概要
- 論文の詳細を見る
To elucidate the anti-inflammatory action of nicotine-induced corticosterone elevation on the passive skin Arthus reaction (PSAR), we investigated the inflammatory process in the PSAR. The polymorphonuclear leukocyte (PMNs) infiltration was observed just before as well as after elicitation by measuring extractable myeloperoxidase. The plasma exudation was significantly inhibited by anti-rat tumor necrosis factor (TNF)-α antibody (5 μg/site, i.d.) at the time of sensitization or by superoxide dismutase (52500 units/kg, i.p.) 1 h before elicitation or NG-nitro-<sc>L</sc>-arginine-methyl ester (100 mg/kg, i.v.) just at elicitation. Pretreatment with a single injection of nicotine (0.8 mg/kg, i.p.) 30 min before elicitation suppressed the plasma exudation but not the PMNs infiltration. This nicotine-induced decreasing effect was abolished in animals supplemented with <sc>L</sc>-arginine (300 mg/kg, i.v.) just at elicitation. The production of nitric oxide (NO) in peritoneal PMNs derived from an animal injected peritoneally with oyster glycogen was significantly suppressed by pretreatment with nicotine (0.8 mg/kg, i.v.) 30 min prior to harvesting. This inhibitory action of nicotine was abolished in animals pretreated with mifepristone (30 mg/kg, s.c.), a glucocorticoid receptor antagonist. These findings indicate that a single systematic administration of nicotine may attenuate the plasma exudation in the PSAR by suppressing the production of NO in the PMNs primed with TNF-α via nicotine-induced endogenous glucocorticoid.
- 社団法人 日本薬理学会の論文
- 2004-01-01
著者
-
NAKASHIMA Toshikatsu
Department of Pharmacology, Nara Medical University
-
Kita Taizo
Department Of Pharmacology Nara Medical University:department Of Pharmacology Daiichi College Of Pha
-
Kita Taizo
Department Of Pharmacology Daiichi College Of Pharmaceutical Sciences
-
KUBO Kaoru
Laboratory Animal Research Center, Nara Medical University
-
Kubo Kaoru
Laboratory Animal Research Center Nara Medical University
-
Tsujimura Takahiro
Department Of Pharmacology Nara Medical University
-
Tsujimura Takahiro
Department Of Clinical Pathology Sumitomo Hospital
-
Nakashima Toshikatsu
Department Of Pharmacology Nara Medical College
関連論文
- Succinate Dehydrogenase Activities of Fibers in the Rat Extensor Digitorum Longus, Soleus, and Cardiac Muscles
- Inhibition of Growth and Metastasis of Ovarian Carcinoma by Administering a Drug Capable of Interfering with Vascular Endothelial Growth Factor Activity
- Current Research on Methamphetamine-Induced Neurotoxicity : Animal Models of Monoamine Disruption
- Cell Size and Oxidative Enzyme Activity of Type-Identified Fibers in Rat Hindlimb Muscles : a Review
- Responses of Exposure to Cigarette Smoke at Three Dosage Levels on Soleus Muscle Fibers in Wistar-Kyoto and Spontaneously Hypertensive Rats
- Fiber Type Distribution, Cross-Sectional Area, and Succinate Dehydrogenase Activity of Soleus and Extensor Digitorum Longus Muscles in Spontaneously Hypertensive Rats
- Cell Size and Oxidative Enzyme Activity of Different Types of Fibers in Different Regions of the Rat Plantaris and Tibialis Anterior Muscles
- Changes of Brain Endothelin Levels and Peripheral Endothelin Receptors by Chronic Cigarette Smoke in Spontaneously Hypertensive Rats
- WIDESPREAD DISTRIBUTION OF HUMAN EPIDERMAL GROWTH FACTOR (hEGF) IN HUMAN TISSUES AND ORGANS UNDER NORMAL AND TUMOROUS CONDITIONS : IMMUNO-HISTOCHEMICAL STUDIES WITH THE USE OF POLYCLONAL AND MONOCLONAL ANTIBODIES
- EXPRESSION OF S-100 PROTEIN, GLIAL FIBRILLARY ACIDIC PROTEIN, NEURON-SPECIFIC ENOLASE, AND KERATIN IN MIXED TUMORS OF SKIN
- Psychological Stress Induces Heat Shock Protein 70 Expression in Rat Aorta
- Peritoneal Serous Papillary Adenocarcinoma: Report of Four Cases
- HETEROTOPIC BONE FORMATION IN TUMOR STROMAL TISSUE : IMMUNOHISTOCHEMICAL CONSIDERATIONS
- Effect of Nicotine-Induced Corticosterone Elevation on Nitric Oxide Production in the Passive Skin Arthus Reaction in Rats
- PENICILLIN G-INDUCED CUTANEOUS ANAPHYLAXIS IN THE GUINEA PIG
- S2-2 Estimation of The Relationship Between Methamphetamine-induced Behavioral Toxicity and Neurotoxicity in Mice.
- Why couldn't an accurate diagnosis be made? An analysis of 1044 consecutive autopsy cases
- Cigarette smoke decreases organic acids levels and population of bifidobacterium in the caecum of rats
- STUDIES ON ALTERNATION OF NICOTINE METABOLIZING ENZYME ACTIVITIES IN VARIOUS SPECIES. (8) : EFFECT OF ADMINISTRATION ROUTE ON RAT
- Cigarette smoke decreases organic acids levels and population of bifidobacterium in the caecum of rats
- Phosphaturic mesenchymal tumor, mixed connective tissue variant (oncogenic osteomalacia)
- Suppressed anti-oxidant capacity due to a cellulose-free diet declines further by cigarette smoke in mice
- Changes of ghrelin and leptin levels in plasma by cigarette smoke in rats
- Suppressed anti-oxidant capacity due to a cellulose-free diet declines further by cigarette smoke in mice
- Effects of nicotine on ambulatory activity in mice.
- Effects of Acute Administration of Nicotine on Convulsive Movements and Blood Levels of Corticosterone in Old Rats.
- Calphostin C, a Potent and Specific Inhibitor of Protein Kinase C, Reduces Phorbol Ester-Induced but Not Primary Ca2+-Induced Catecholamine Secretion from Digitonin-Permeabilized Bovine Adrenal Medullary Cells.
- Tolerance to the Convulsions Induced by Daily Nicotine Treatment in Rats.