WIDESPREAD DISTRIBUTION OF HUMAN EPIDERMAL GROWTH FACTOR (hEGF) IN HUMAN TISSUES AND ORGANS UNDER NORMAL AND TUMOROUS CONDITIONS : IMMUNO-HISTOCHEMICAL STUDIES WITH THE USE OF POLYCLONAL AND MONOCLONAL ANTIBODIES
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概要
- 論文の詳細を見る
Immunohistochemiccal expression of human epidermal growth factor (hEGF) in human tissues and organs is described by the use of polyclonal anti-hEGF antiserum and monoclonal antibody to hEGF generated by the synthetic gene technique. In the digestive system, salivary gland ducts, centro-acinar cells in the pancreas, fundic glands and pylorus glandular epithelium, Brunner's gland, Paneth cells, and hepatic cells showed a positive hEGF reaction. Bronchial glands indicated positive staining in their serous acinar cells and ducts. Kidney contained abundant staining for hEGF in distal convoluted tubules and in some cells of collecting tubules where polyclonal antiserum was used. The prostate gland showed strong hEGF deposition in its epithelium. Mammary gland epithelium, secretory coil cells of the sweat glands, and endometrial glands indicated a positive reaction. In genitalia, Leydig cells of the testis, and lutein cells of the ovary including those in the ovary during pregnancy, indicated the presence of hEGF. In the endocrine organs, acidophilic cells of the anterior pituitary, some cells in its neuro-hypophysis, follicular cells of the thyroid, acidophilic cells of the parathyroid glands, and the cells in the fasciculus and reticularis of the adrenal glands showed positive staining. We also found comparatively intense hEGF staining in the epithelial components of various neoplastic lesions, such as salivary plemorphic adenoma, gastric cancer, pancreatic adenocarcinoma, epithelial tumor cells in Wilms tumor, ovarian adenocarcinoma, adenomatous cells of hypertrophied prostate, seminoma and embryonal carcinoma in the testis, decidual cells of hydatidiform mole, mammary adenocarcinoma, oxyphilic adenoma and follicular adenoma in the thyroid, oxyphilic cells of parathyroid adenoma, compact cells of adrenocortical adenoma, and pheochromocytoma cells.
- 日本組織細胞化学会の論文
著者
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MORI Masahiko
Department of Oral Pathology, Osaka Dental University
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Mori M
Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry:medicaraise Corporatio
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Mori Masahiko
Department Of Oral Pathology Osaka Dental University
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Mori M
Department Of Oral Surgery Asahi University School Of Dentistry
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TSUKITANI KOUJI
Department of Dentistry, Kyoto Prefectural University of Medicine
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OKADA YUKIO
Department of Oral Surgery, Asahi University School of Dentistry
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Okada Y
Sapporo Medical Univ. School Of Medicine Hokkaido
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TSUJIMURA Takahiro
Department of Pathology, Sumitomo Hospital
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NAITO RYOJI
Department of Oral Surgery, Gifu College of Dentistry
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Naito Ryoji
Department Of Oral Surgery Asahi University School Of Dentistry
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Okada Y
Sapporo Breweries Ltd. Gunma Jpn
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Okada Yukio
Division Of Integrative Sensory Physiology Department Of Developmental And Reconstructive Medicine N
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Okada Yukio
Department Of Oral Surgery Asahi University School Of Dentistry
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Okada Y
Division Of Integrative Sensory Physiology Department Of Developmental And Reconstructive Medicine N
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Muto Masahiro
Department Of Oral Pathology Osaka Dental University
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Tsujimura Takahiro
Department Of Clinical Pathology Sumitomo Hospital
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Mori Masahiko
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry
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Tsukitani Kouji
Department Of Oral & Maxillofacial Surgery Kyoto Prefectural University Of Medicine
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Mori Masahiko
Department Of Applied Chemistry Faculy Of Engineering And High Technology Research Center Kansai Uni
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Okada Yukio
Department Of Oral Surgery Asahi University School Of Dentistory
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