Identification of a New G-to-A Transition Mutation at Nucleotide Position 129 of the Xrcc4 Gene in Ionizing Radiation-hypersensitive Mutant LX830 Cells
スポンサーリンク
概要
- 論文の詳細を見る
The mouse lymphoma cell line LX830 is an X-ray-hypersensitive mutant. Complementation tests between LX830 cells and radiation-sensitive mutants of M10 (Xrcc4 deficient cells) or SX10 (DNA ligase IV deficient cells) cells showed that M10 cells did not complement LX830 cells, but SX10 cells did, suggesting that LX830 cells would belong to the X-ray-cross complementation group (XRCC4). A sequence analysis of Xrcc4 cDNA in LX830 cells disclosed a transition of G to A at nucleotide position 129, which resulted in a change of tryptophan (43) to a termination codon. Transfection of the mouse Xrcc4 cDNA rescued the X-ray sensitivity of the mutant cells. LX830 is an Xrcc4-deficient cell line bearing a termination codon in exon 2 of the Xrcc4 gene and no wild-type Xrcc4 gene.
- 日本放射線影響学会の論文
- 2003-12-15
著者
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Mori M
Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry:medicaraise Corporatio
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Mori Masahiko
Department Of Oral Pathology Osaka Dental University
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Mori M
Department Of Oral And Maxillofacial Surgery School Of Dentistry Asahi University
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Mori M
Department Of Oral Surgery Asahi University School Of Dentistry
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Mori M
Department Of Oral Surgery Gifu College Of Dentistry
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ITSUKAICHI Hiromi
Radiation Hazards Research Groupe, Natl. Inst. Radiat, Sci.
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MORI MASAHIKO
Radiation Hazard Research Group, National Institute of Radiological Sciences
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Itsukaichi Hiromi
Radiation Hazards Research Group National Institute Of Radiological Sciences
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Mori Masahiko
Takasago Research & Development Center Mitsubishi Heavy Industries Ltd.
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Mori Masahiko
Radiation Hazards Research Group National Institute Of Radiological Sciences
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Sato K
Jaeri Tokai:fac. Sci. Ibaraki Univ.
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Sato Koki
Department Of Hygiene Hirosaki University School Of Medicine
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Sato Koki
放射線医学総合研究所
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NAKAMURA Atsuko
Radiation Hazards Research Group, Natl. Inst. Radiol. Sci.
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Nakamura Atsuko
Radiation Hazards Research Group National Institute Of Radiological Sciences
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Itsukaichi Hiromi
Div. Radiat. Biol. &biodosimet. Natl. Inst. Radiol. Sci.
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SATO Koki
School of Biology-oriented Science and Thechnology Kinki Univ.
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Muto Masahiro
Department Of Oral Pathology Osaka Dental University
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Sato Koki
Department Of Electrical Engineering Shonan Institute Of Technology
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Nakamura Atsuko
Radiation Hazards Research Group Natl. Inst. Radiol. Sci.
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Mori Masahiko
Radiation Effect Mechanisms Research Group Research Center For Radiation Protection National Institute Of Radiological Sciences
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Sato Kiyoshi
Departments Of Neurosurgery
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Sato Koki
Department of Applied Computer Sciences, Shonan Institute of Technology, Fujisawa, Kanagawa 251-8511, Japan
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