IMMUNOHISTOCHEMICAL EVALUATION OF KERATIN AND INVOLUCRIN DISTRIBUTION IN BOWEN'S DISEASE
スポンサーリンク
概要
- 論文の詳細を見る
Specimens from patients with Bowen's disease were studied for keratin and involucrin distribution as determined by antibodies (polyclonal (TK), and monoclonal (KL1 and PKK1) against keratin, and polyclonal antibodies against involucrin, respectively. Squamous cells in normal skin were positive for TK detectable keratins throughout the epidermis, while the spinous cells were strongly positive for KL1 detectable ones. Basal cells were negative for KL1, but characteristically strongly positive for PKK1. Normal epidernis showed marked staining for involucrin in upper spinous and granular cell layers. Specimens from patients with Bowen's disease exhibited irregular expression of antigen by the three types of anti-keratin, antibodies with a loss of the regular or zonal distribution pattern as found in the normal epidermis. The lesions also showed negative staining for involucrin. Thus, affected epithelial cells in Bowen's disease showed marked differences in stainability with respect to present four inmunoreagents.
- 日本組織細胞化学会の論文
著者
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住友 伸一郎
朝日大学歯学部口腔病態医療学講座口腔外科学分野
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MORI Masahiko
Department of Oral Pathology, Osaka Dental University
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Mori Masahiko
Department Of Oral Pathology Osaka Dental University
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Mori M
Department Of Oral Surgery Asahi University School Of Dentistry
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TATEMOTO YUKIHIRO
Department of Oral and Maxillofacial Surgery, Kochi Medical School
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SUMITOMO SHINICHIRO
Department of Oral Surgery, Gifu College of Dentistry
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TANIMURA TAKAHUMI
Department of Oral Surgery, Asahi University School of Dentistry
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REIBEL JESPER
Department of Oral Pathology, The Royal Dental College, Panum Institute
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Tanaka Toshikazu
Department Of Anatomy Faculty Of Medicine Kyoto University
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Tanaka Takaaki
Department Of Oral Surgery Asahi University School Of Dentistry
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Tanaka T
Department Of Oral Anatomy And Cell Biology Graduate School Of Dental Sciences Kyushu University
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Tanaka Tomoo
Division Of Basic Medical Sciences Tokai University School Of Medicine
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Reibel Jesper
Department Of Oral Pathology The Royal Dental College Panum Institute
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Tatemoto Yukihiro
Department Of Oral Surgery Asahi University School Of Dentistry
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Mori Masahiko
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry
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Mori Masahiko
Department Of Applied Chemistry Faculy Of Engineering And High Technology Research Center Kansai Uni
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