HISTOCHEMICAL OBSERVATION OF NADP-DEPENDENT ISOCITRATE AND GLUCOSE-6-PHOSPHATE DEHYDROGENASES IN THE HUMAN NEOPLASMS

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Histochemical investigations of NADP-dependent glucose-6-phosphate and isocitrate dehydeogenases on the 663 cases of human tumors, benign or malignant, were made with Nitro BT as an electron acceptor. In the enzymatic distribution patterns of human tumors, these dehydrogenases of epidermoid carcinoma were presented in the para or dyskeratotic regions; the activities in gastrointestinal malignancies were varying in neoplastic epithelia and almost negative in stromal tissues. The breast tumors examined were clearly distinguished into two groups; one consisted of benign tumors and normal tissues. showing low enzymatic activities, and the other, malignant tumors with diffuse invasion, showing high enzymatic activities. Of the two types of renal carcinoma, a granulosa cell type, strongly reacted, while a clear cell type weakly responded to the two dehydrogenases. Transitional cell carcinoma generally showed high activities in neoplastic cells. Glucose-6-phosphate dehydrogenase activity of gliomas was low, while that in metaplastic or malignant types was usually high. The neoplastic cells of ovarian tumors were most reactive to glucose-6-phosphate dehydrogenase, and some stromal cells and those adjacent to tumor epithelia of solid ovarian tumor were characterized by the occasional presence of the highest glucose-6-phosphate dehydrogenase activity suggesting the steroid production. Chorionic tumor displayed the highest activity in neoplastic villi and trophoblastic tumor cells. Adrenal gland adenoma was highly positive for the two dehydrogenases irrespective of the presence or the absence of the endoclinological syndromes.
日本組織細胞化学会の論文

HISTOCHEMICAL OBSERVATION OF NADP-DEPENDENT ISOCITRATE AND GLUCOSE-6-PHOSPHATE DEHYDROGENASES IN THE HUMAN NEOPLASMS

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