Early Growth of Experimental Lung Metastasis in Mouse
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概要
- 論文の詳細を見る
A radiobiological method was developed to measure the initial growth of clonogenic tumor cells metastasizing to the lung. The thoraxes of mice were externally irradiated by γ rays after an intravenous transplantation of syngeneic fibrosarcoma cells. The lung colonies which developed 11 days after irradiation were counted and provided surviving fractions. Survival curves moved downward when the time interval between transplantation and radiation was delayed from 1 to 21hr, but shifted upward at 48hr or later. Survival ratios at given doses and the extrapolation number of survival curves fitted to multi-target model were calculated, and plotted against time after the intravenous transplantation. Doubling times of 13.3 and 13.1hr were obtained by use of the survival ratio and of the extrapolation number, respectively. This method is useful to measure the growth dynamics of clonogenic tumor cells at the site of a metastasized organ.
- 日本放射線影響学会の論文
- 2005-06-30
著者
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安藤 興一
放医研
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安藤 興一
学振科技特
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安藤 興一
Natl. Instit. Rad. Sci. Med.
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Ando Koichi
Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences
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笹井 啓資
新潟大学医学部放射線医学講座
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小池 幸子
放射線医学総合研究所重粒子医科学センター粒子線生物研究グループ
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小池 幸子
北里大学 獣医学部
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Sasai Keisuke
Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences
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KOIKE Sachiko
Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit
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Ando K
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Ando Koichi
Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences
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Shibuya Keiko
Department Of Radiation Oncology And Image-applied Therapy Kyoto University Hospital
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Koike Sachiko
Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences
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Koike Sachiko
Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences
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Sasai Keisuke
京都大学 放射腺腫瘍学･画像応用療学
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KOIKE Sachiko
National Inst. of Radiol. Sci
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Ando Soichiro
National Institute Of Radiological Sciences
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Ando Koichi
Department Of Technical Support And Development Natl. Inst. Radiol. Sci.
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Ando Koichi
Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences
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Koike Sachiko
Research Center For Charged Particle Therapy Natl. Inst. Radiol. Sci.
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HORI Nobukazu
Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences
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Ando Koichi
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Hori Nobukazu
Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences:department Of Surg
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Sasai Keisuke
Department Of Radilogy And Nuclear Medicine Faculty Of Medicine Kyoto University
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Koike Sachiko
Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut
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Ando Koichi
Heavy-ion Radio. Res. Nirs
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Ando Koichi
International Space Radiation Laboratory National Institute Of Radiological Sciences
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