Reductive Dechlorination of p, p'-DDT Mediated by Hemoproteins in the Hepatopancreas and Blood of Goldfish, Carassius auratus
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概要
- 論文の詳細を見る
The in vitro metabolism of p, p'-DDT (p, p'-dichlorodiphenyltrichloroethane), an important environmental pollutant, was examined in fish, focusing on reductive dechlorination. When p, p'-DDT was incubated with hepatopancreas microsomes or the blood of goldfish, Carassius auratus, in the presence of both a reduced pyridine nucleotide and FMN, a dechlorinated metabolite, p, p'-DDD (p, p'-dichlorodiphenyldichloroethane) was formed under anaerobic conditions. These reductase activities were inhibited by carbon monoxide. Although the microsomes or blood was boiled, the dechlorinating activity was not abolished. Hemoglobin and hematin exhibited the reductase activity toward p, p'-DDT with NADH and FMN. The activity of hematin was also exhibited with FMNH_2. The reductive dechlorination appears to proceed nonenzymatically by the reduced flavin, catalyzed by the heme group of hemoproteins.
- 社団法人日本薬学会の論文
- 1999-08-31
著者
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KITAMURA Shigeyuki
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Kitamura Shigeyuki
広島大学原爆放射能医学研究所
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Yoshida Miki
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Sugihara K
Graduate School Of Biomedical Sciences Hiroshima University
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Sugihara Kazumi
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Yoshida M
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Yoshida Mayumi
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Ohta Shigeru
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Ohta Shigeru
Institute Of Materials Science University Of Tsukuba
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Kitamura Shigeyuki
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Yasuda Mineo
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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