METABOLISM OF N-HYDROXYURETHANE BY GUINEA PIG LIVER PREPARATIONS
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概要
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The present study demonstrated the metabolism of N-hydroxyurethane by cell-free preparations, i.e., 9000×g supernatant, cytosol and microsomes, from guinea pig livers. Under anaerobic conditions, the metabolizing activities of these preparations were enhanced markedly by addition of both an NADPH-or NADH-generating system and FAD. When the 30-45% ammonium sulfate fraction from liver cytosol was combined with liver microsomes or milk xanthine oxidase, the metabolic reaction of N-hydroxyurethane proceeded to a greater extent. Thin-layer chromatographic examination showed that urethane was only a metabolite formed from N-hydroxyurethane by these preparations.
- 公益社団法人日本薬学会の論文
著者
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TATSUMI Kiyoshi
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Tatsumi Kiyoshi
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Sugihara Kazumi
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Sugihara Kazumi
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Kawazoe Yuichi
Faculty Of Pharmaceutical Sciences Kyushu University
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