STUDIES ON BACTERIAL NITROREDUCTASES. ENZYMES INVOLVED IN REDUCTION OF AROMATIC NITRO COMPOUNDS IN ESCHERICHIA COLI
スポンサーリンク
概要
- 論文の詳細を見る
Enzymes involved in reduction of methyl p-nitrobenzoate in Escherichia coli B/r were oxygen-insensitive and precipitated between 30 and 60% ammonium sulfate saturation from cell-free extracts of the strain. The reductases were resolved by DEAE-cellulose column chromatography into three enzymes, NADH-linked, NAD (P) H-linked and NADPH-linked ones. These enzymes were flavoprotein which could be inactivated by dialysis aginst 1 M potassium bromide and could be reactivated by FMN. The NADH-linked and NAD (P) H-linked reductases were sensitive to dicumarol and exhibited menadione reductase activities. Aromatic nitro compounds with electron-withdrawing p-substituents were easily reduced by the NAD (P) H-linked reductase.
- 公益社団法人日本薬学会の論文
著者
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KITAMURA Shigeyuki
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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TATSUMI Kiyoshi
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Tatsumi Kiyoshi
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Tatsumi Kiyoshi
Institute Of Pharmaceutical Science. Hiroshima University School Of Medicine
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NARAI NORIKO
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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Narai Noriko
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine:(present Address)facult
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Kitamura Shigeyuki
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Kitamura Shigeyuki
Institute Of Pharmaceutical Science. Hiroshima University School Of Medicine
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TATSUMI KIYOSHI
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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