Synthesis of Deuterium-Labeled Flavanones
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概要
- 論文の詳細を見る
Deuterium incorporation at the C-3 position of flavanones was achieved by treatment of flavanones and 2'-hydroxychalcones with D_3PO_4 and AcOD. We propose that the deuteration reaction mechanism for 2'-hydroxy-chalcones substrates is as follows. In the first step, 2'-hydroxychalcones cyclize to the corresponding flavanones by an intramolecular Michael-type reaction. Then deuteriums are incorporated into the flavanones via enolization.
- 公益社団法人日本薬学会の論文
- 2004-08-01
著者
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OHTA Shigeru
Graduate School of Biomedical Sciences, Hiroshima University
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Takahashi Tetsuya
Department of Internal Medicine, Chibune Hospital
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Ohta S
Graduate School Of Biomedical Sciences Hiroshima University
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KAGAWA Hitoshi
Department of Organic Synthesis, School of Pharmaceutical Sciences, Kitasato University
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HARIGAYA Yoshihiro
Department of Organic Synthesis, School of Pharmaceutical Sciences, Kitasato University
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UNO Mariko
Department of Organic Synthesis, School of Pharmaceutical Sciences, Kitasato University
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Ohta Shigeru
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Uno Mariko
Department Of Organic Synthesis School Of Pharmaceutical Sciences Kitasato University
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Kagawa Hitoshi
Department Of Organic Synthesis School Of Pharmaceutical Sciences Kitasato University
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Ohta Shigeru
Graduate School Of Biomedical Sciences Hiroshima Univ.
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Takahashi Tetsuya
Department Of Avian Endocrinology Gifu University
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Takahashi Tetsuya
Department Of Organic Synthesis School Of Pharmaceutical Sciences Kitasato University
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Harigaya Y
School Of Pharmacy Kitasato University
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Harigaya Yoshihiro
Department Of Organic Synthesis School Of Pharmaceutical Sciences Kitasato University
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