Identification and Determination of Cannabinoids in both Commercially Available and Cannabis Oils Stored Long Term

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概要

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• Among cannabinoids (CNs) in two commercially available and long-term stored cannabis oils obtained from the seeds of Cannabis sativa L. in Japan, tetrahydrocannabinol (THC), canabidiol (CBD), cannabinol (CBN), and cannabichromene were identified and determined using high-performance thin-layer chromatography and capillary gas chromatography-mass speectrometry after partitioning extraction with n-hexane/acetonitrile. CNs were determined in two commercially available cannabis oils, designated "Hemp oil" (THC, 16.3μg/g and CBN, 5.9μg/g) and "Taima-yu" (CBD, 26.1μg/g). The concentration of CBD in a cannabis oil that had been stored for 20 years was 107±4μg/g. However, no other CNs including THC were detected in the oil. The CBD content in the original oil was estimated to be about 130μg/g from the determination values of the two periods. These results suggest that cannabis oils generally contain CNs to some extent.

• 公益社団法人日本薬学会の論文
• 2005-08-01

著者

• Sekita Setsuko

  Tsukuba Medicinal Plant Research Station National Institute Of Health Sciences

• WATANABE Kazuhito

  Faculty of Pharmaceutical Sciences, Hokuriku University

• YAMAMOTO Ikuo

  School of Pharmaceutical Sciences, Kyushu University of Health and Welfare

• Sekita Setsuko

  愛知県衛生研究所

• Yotoriyama Mamoru

  Tochigi Prefectural Institute of Public Health and Environment

• Ishiharajima Eiji

  Tochigi Prefectural Institute of Public Health and Environment

• Kato Yoko

  Tochigi Prefectural Institute of Public Health and Environment

• Nagato Akiko

  Tochigi Prefectural Institute of Public Health and Environment

• Watanabe Kazuhito

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Yamamoto Ikuo

  School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare

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