Pharmacologically Active Components of Viticis Fructus (Vitex rotundifolia). II. The Component Having Analgesic Effects
スポンサーリンク
概要
- 論文の詳細を見る
The extract of Viticis Fructus appeared to have an analgesic effect, and was subjected to activity-guided separation using acetic acid-induced writhing in mice. The active fraction gave new compounds, vitexfolin A (1A), B and C, 10-O-vanilloylaucubin (3), dihydrodehydrodiconiferylalcohol-β-D-(2'-O-p-hydroxybenzoyl)glucoside (4), and vanilloyl-β-D-(2'-O-p-hydroxybenzoyl)glucoside, together with agnuside (2) and eryhro- and threo-guaiacylglycerols. Compounds 1A and 2-4 showed significant writhing inhibition following oral administration at doses of 15,50,25,and 50 mg/kg, respectively The effect on pressure pain threshold was tested using compounds 1A and 2 at a dose of 50 mg/kg, and only the former produced the analgesia. The analgesic effect of some related iridoid glucosides is also discussed.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
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山崎 幹夫
千葉大学薬学部
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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奥山 恵美
千葉大学 院薬
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OKUYAMA Emi
Faculty of Pharmaceutical Sciences, Chiba University
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YAMAZAKI Mikio
Faculty of Pharmaceutical Sciences, Chiba University
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Okuyama Emi
Faculty Of Pharmaceutical Science Chiba University
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OKUYAMA Emi
Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University
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FUJIMORI Shigeru
Faculty of Pharmaceutical Sciences
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DEYAMA Takeshi
Yomeishu Seizo Co., Ltd.,
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Deyama T
Central Research Laboratories Yomeishu Seizo Co. Ltd.
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Okuyama E
Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University
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Yamazaki Mikio
Faculty Of Pharmaceutical Sciences Chiba University
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