Enhancement of Phenylephrine-Induced Contraction in the Isolated Rat Aorta With Endothelium by H_2O-Extract From an Oriental Medicinal Plant Leonuri herba
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概要
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Leonuri herba (I-mu-tsao, the Chinese motherwort) is an ancient Chinese traditional herb. Although the pharmacological effects of extracts of Leonuri herba have been shown in platelets and uteri, the effect on the vascular system has not been determined. In the present study, we investigated the effects of extracts of Leonuri herba on the contraction of the isolated rat aorta. Although the H2O-extract (0.3 - 3 mg/ml) by itself showed a limited effect, the extract enhanced phenylephrine-induced contraction of the aorta with endothelium, but not without endothelium. The H2O-extract, like NG-nitro-L-arginine methyl ester (L-NAME, an inhibitor of nitric oxide synthase), significantly inhibited the relaxation induced by acetylcholine in the aorta with endothelium. The inhibitory effect of H2O-extract on the relaxation decreased by co-addition with 1 mM L-arginine. The vasoconstrictive effect of H2O-extract was not due to leonurine, which is a constituent in Leonuri herba and shows uterotonic activity. Intravenous injection of the H2O-extract (1.5 mg/kg) to rats caused an increase in blood pressure for 5 min, like L-NAME (1.35 mg/kg). These findings suggest that there is a component(s) in Leonuri herba, which shows a vasoconstrictive activity in rat aorta in vitro and in vivo and has similar pharmacological profile to that of L-NAME.
- 社団法人 日本薬理学会の論文
- 2001-06-01
著者
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MURAYAMA Toshihiko
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
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UCHIDA Masayuki
Food Science Institute, Division of Research and Development, Meiji Dairies Corporation
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Sekine T
Graduate School Of Pharmaceutical Sciences Chiba University
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Horie Syunji
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Josai International University
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Horie Syunji
Laboratory Of Chemical Pharmacology Chiba University
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Murayama T
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
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Murayama Toshihiko
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
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Murayama Toshihiko
Laboratory Of Chemical Pharamacology Graduate School Of Pharmaceutical Sciences Chiba University
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WATANABE Kazuo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Facul
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Horie S
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Murayama Toshihiko
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ. Jpn
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PANG Shanling
Laboratory of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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TSUCHIYA Shizuko
Laboratory of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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Pang Shanling
Laboratory Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Uchida Masayuki
Food Functionality Research Institute Division Of Research And Development Meiji Dairies Corporation
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Tsuchiya Shizuko
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
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Tsuchiya Shizuko
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Watanabe Kazuo
Hokkaido Pharmaceutical University School Of Pharmacy
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Watanabe Kazuo
Laboratory Of Chemical Pharmacology Department Of Drug Evaluation And Toxicological Sciences Faculty
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Uchida Masayuki
Food Functionality Research Institute Meiji Milk Products Co.
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Tsuchiya Shizuko
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Tsuchiya Shizuko
Dept Of Mol. Pharmacol. & Pharmacother Grad. Sch. Pharm. Sci. Chiba Univ.
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Watanabe Kazuo
Laboratory Of Applied Botany Faculty Of Agriculture Kyoto University
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Watanabe Kazuo
Laboratory Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Tsuchiya Shizuko
Laboratory Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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