Regulatory Mechanism and Physiological Role of Cytosolic Phospholipase A_2(Diversity of Phospholipase A_2 Enzymes)
スポンサーリンク
概要
- 論文の詳細を見る
Cytosolic phospholipase A_2α (cPLA_2α) preferentially hydrolyzes phospholipids containing arachidonic acid and plays a key role in the biosynthesis of eicosanoids. This review discusses the essential features of cPLA_2α regulation and addresses new insights into the functional properties of this enzyme. Full activation of the enzyme requires Ca^<2+> binding to an N-terminal C2 domain and phosphorylation on serine residues. Ca^<2+> binding induces translocation of cPLA_2αfrom the cytosol to the perinuclear membranes. Serine phosphorylation is mediated by mitogen-activated protein kinases (MAPKs), Ca^<2+>/calmodulin-dependent protein kinase II, and MAPK-interacting kinase Mnk1. Interaction with proteins and lipids, which include vimentin, annexins, NADPH oxidase, phosphatidylcholine, phosphatidylinositol 4,5-bisphosphate (PIP_2), and ceramide-1-phosphate, can also modulate the activity of cPLA_2α. Recent evidence has established the physiological and pathological roles of cPLA_2α using cPLA_2α knockout mice. This enzyme has been implicated in fertility, striated muscle growth, renal concentration, postischemic brain injury, arthritis, inflammatory bone resorption, intestinal polyposis, pulmonary fibrosis, acute respiratory distress syndrome, and autoimmune encephalomyelitis. Now novel three paralogs, cPLA_2β, cPLA_2γ, and cPLA_2δ, have been identified in humans. cPLA_2γ is distinct from others in that it is farnesylated and lacks the C2 domain. Biological roles for these new enzymes have not yet been defined.
- 公益社団法人日本薬学会の論文
- 2004-08-01
著者
-
Murayama T
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Murayama Toshihiko
Laboratory Of Chemical Pharamacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Murayama Toshihiko
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ. Jpn
-
Shimizu Takao
Department Of Biochemistry And Molecular Biology Faculty Of Medicine The University Of Tokyo
-
HIRABAYASHI Tetsuya
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
-
Hirabayashi Tetsuya
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
関連論文
- Effects of Synthetic Sphingosine-1-Phosphate Analogs on Cytosolic Phospholipase A2α–Independent Release of Arachidonic Acid and Cell Toxicity in L929 Fibrosarcoma Cells: the Structure–Activity Relationship
- Activation of Cytosolic Phospholipase A_2α by Epidermal Growth Factor (EGF) and Phorbol Ester in HeLa Cells : Different Effects of Inhibitors for EGF Receptor, Protein Kinase C, Src, and C-Raf
- Effects of Synthetic Sphingosine-1-Phosphate Analogs on Cytosolic Phospholipase A_2α-Independent Release of Arachidonic Acid and Cell Toxicity in L929 Fibrosarcoma Cells : the Structure-Activity Relationship
- Activation of Cytosolic Phospholipase A2α by Epidermal Growth Factor (EGF) and Phorbol Ester in HeLa Cells: Different Effects of Inhibitors for EGF Receptor, Protein Kinase C, Src, and C-Raf
- Inhibition of Cytosolic Phospholipase A_2 Suppresses Production of Cholesteryl Ester through the Reesterification of Free Cholesterol but not Formation of Foam Cells in Oxidized LDL-Stimulated Macrophages(Highlighted paper selected by Editor-in-chief,Bioc
- Depressive Behavior and Alterations in Receptors for Dopamine and 5-Hydroxytryptamine in the Brain of the Senescence Accelerated Mouse (SAM)-P10
- Focused lipidomics by tandem mass spectrometry
- Specific Detection of Lysophosphatidic Acids in Serum Extracts by Tandem Mass Spectrometry
- Prognostic significance of second-look laparotomy for surgically confirmed early-stage epithelial ovarian cancer : a multicenter retrospective study
- Characteristic Upregulation of Dopamine D_1-Receptor in Rat Striatum after 6-Hydroxydopamine Treatment
- Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway
- Platelet-Activating Factor Receptor
- Arachidonic Acid Metabolites Inhibit the Stimulatory Effect of Angiotensin II in Renal Proximal Tubules
- The Majority of Lymphocytes in the Bone Marrow, Thymus and Extrathymic T Cells in the Liver Are Generated In Situ from Their Own Preexisting Precursors
- Possible Role of Interleukin-6 in PC12 Cell Death Induced by MPP^+ and Tetrahydroisoquinoline
- Leukotriene Receptors : Classification, Gene Expression, and Signal Transduction
- Expression of Cytosolic Phospholipase A_2α in Murine C12 Cells, a Variant of L929 Cells, Induces Arachidonic Acid Release in Response to Phorbol Myristate Acetate and Ca^ Ionophores, but Not to Tumor Necrosis Factor-α
- Extracellular Signal Regulated Protein Kinase and c-Jun N-Terminal Kinase are Involved in m1 Muscarinic Receptor-Enhanced Interleukin-2 Production Pathway in Jurkat Cells
- Nicotine-Induced Neurogenic Relaxation in the Mouse Colon : Changes With Dextran Sodium Sulfate-Induced Colitis
- Roles of nitric oxide as a vasodilator in neurovascular coupling of mouse somatosensory cortex
- Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B_4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13-Reductase Complex Reveals the Structural Basis of Broad Spectrum Indomethacin Efficacy
- Indomethacin Decreases Arachidonic Acid Uptake in HCA-7 Human Colon Cancer Cells
- Enhancement of Phenylephrine-Induced Contraction in the Isolated Rat Aorta With Endothelium by H_2O-Extract From an Oriental Medicinal Plant Leonuri herba
- Increases in plasma concentration of progesterone by protease-sensitive urinary pheromones in female rats
- Lafutidine-Induced Increase in Intracellular Ca^ Concentrations in PC12 and Endothelial Cells
- Multiple gastrinoma successfully resected with the aid of intraoperative arterial secretin injection test
- Global analysis of triacylglycerols including oxidized molecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS
- Vosorelaxing Effect of Mesaconitine, an Alkaloid From Aconitum japonicum, on Rat Small Gastric Artery : Possible Involvement of Endothelium-Derived Hyperpolarizing Factor
- Quercetin-Induced PC12 Cell Death Accompanied by Caspase-Mediated DNA Fragmentation(Pharmacology)
- Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of κ-Opioid Receptor, in Urethane-Anesthetized Rats
- Separation and quantification of sn-1 and sn-2 fatty acid positional isomers in phosphatidylcholine by RPLC-ESIMS/MS
- Analysis of oxidized phosphatidylcholines as markers for oxidative stress, using multiple reaction monitoring with theoretically expanded data sets with reversed-phase liquid chromatography/tandem mass spectrometry
- Effective Extraction and Analysis for Lysophosphatidic Acids and Their Precursors in Human Plasma Using Electrospray Ionization Mass Spectrometry
- Lafutidine-Induced Increase in Intracellular Ca2+ Concentrations in PC12 and Endothelial Cells
- Modifications of Capsaicin-Sensitive Neurons in Isolated Guinea Pig Ileum by [6]-Gingerol and Lafutidine
- Role of Deacetylation in the Nonlinear Pharmacokinetics of Sulfamonomethoxine in Pigs
- Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
- Changes in the Level of 7α-Hydroxy-3-oxo-4-cholestenoic Acid in Cerebrospinal Fluid after Subarachnoid Hemorrhage
- Regulatory Mechanism and Physiological Role of Cytosolic Phospholipase A_2(Diversity of Phospholipase A_2 Enzymes)
- Nicotine-Induced Neurogenic Relaxation in the Mouse Colon: Changes With Dextran Sodium Sulfate–Induced Colitis
- Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase-Mediated Pathway
- Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-β1-induced expression of α-smooth muscle actin in human fetal lung fibroblasts
- Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
- Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells
- Mechanisms of veratramine-induced 5-HT syndrome in mice.
- Expression of Cytosolic Phospholipase A2.ALPHA. in Murine C12 Cells, a Variant of L929 Cells, Induces Arachidonic Acid Release in Response to Phorbol Myristate Acetate and Ca2+ Ionophores, but Not to Tumor Necrosis Factor-.ALPHA.
- Platelet-Activating Factor Receptor.