Mechanisms of veratramine-induced 5-HT syndrome in mice.
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概要
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Regional monoamine assays revealed that during veratramine-induced myoclonic movements, the contents of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the cerebral cortex were reduced with a slight increase in dopamine metabolites in the midbrain and brainstem. A similar tendency to decrease 5-HT and 5-HIAA contents was observed in the hypothalamus and hippocampus without increase in the contents of dopamine and its metabolites. Norepinephrine levels were not modified in any brain region at any time after the administration of the veratrum alkaloid. It was found that the veratramine evoked <SUP>3</SUP>H-5-HT release from the frontal cortical slices was Ca<SUP>++</SUP>-independent and persistent, and it continued approximately 20 min after the 2-min exposure to veratramine. The uptake of <SUP>3</SUP>H-5-HT into the frontal cortical slices was inhibited competitively by veratramine. These results suggest that veratramine is both a releaser and uptake inhibitor of 5-HT and that the veratramine-induced involuntary movements may be mediated by serotonergic hyperfunction.
- 公益社団法人 日本薬理学会の論文
著者
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Fukuda Takeo
Department Of Pharmacology Faculty Of Medicine University Of Kagoshima
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Iwata Shin-ichi
Department Of Pharmacology Faculty Of Medicine Kagoshima University
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Shimizu Takao
Department Of Biochemistry And Molecular Biology Faculty Of Medicine The University Of Tokyo
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NAGATA Ryoichi
Department of Pharmacology, Faculty of Medicine, Kagoshima University
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IZUMI Kanji
Department of Pharmacology, Faculty of Medicine, Kagoshima University
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Shimizu Takao
Department of Pharmacology, Faculty of Medicine, Kagoshima University
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