Changes in the Level of 7α-Hydroxy-3-oxo-4-cholestenoic Acid in Cerebrospinal Fluid after Subarachnoid Hemorrhage
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概要
- 論文の詳細を見る
A high concentration of a type of cholic acid, 7α-hydroxy-3-oxo-4-cholestenoic acid, is observed in the content of chronic subdural hematoma. To investigate the possible causes, the level of this compound was measured in the cerebrospinal fluid of patients who underwent surgery for aneurysmal subarachnoid hemorrhage or non-hemorrhagic diseases. The maximum level was significantly higher in the aneurysmal subarachnoid hemorrhage patients, indicating that surgical intervention did not cause the postoperative increase in the level of this compound in the cerebrospinal fluid. Monitoring of plasma levels showed no postoperative increase. In vitro culture of a mixture of arterial blood and cerebrospinal fluid failed to show the de novo production of this compound. These results strongly suggest extrahepatic intracranial production of this cholic acid occurs in subarachnoid hemorrhage. The high concentration of this compound in both chronic subdural hematoma and subarachnoid hemorrhage suggests a possible role for 7α-hydroxy-3-oxo-4-cholestenoic acid in intracranial hemorrhagic disorders.
- 日本脳神経外科学会の論文
- 1995-05-15
著者
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SHIMIZU Takao
Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo
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Nagata Kazuya
Department Of Neurosurgery Showa General Hospital
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Nagata Kazuya
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo:department Of Neurosurgery Shin-t
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Seyama Yousuke
Department Of Biochemistry Faculty Of Medicine
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Shimizu Takao
Department Of Biochemistry And Molecular Biology Faculty Of Medicine The University Of Tokyo
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Shimizu Takao
Department Of Biochemistry Faculty Of Medicine The University Of Tokyo
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