Effects of β-Blockers and Nicardipine on Oxotremorine-Induced Tremor in Common Marmosets
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概要
- 論文の詳細を見る
Effects of β-blockers (propranolol, arotinolol and nipradilol) and a Ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. Generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. Intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. The total intensity of oxotremorine-induced tremor for each drug was expressed as “points”, which were the sum of tremor intensity scores evaluated every 10 min up to 190 min following the administration of oxotremorine. β-Blockers significantly suppressed the tremor. On the other hand, the Ca2+ channel blocker exacerbated the tremor.
- 社団法人 日本薬理学会の論文
著者
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Nomoto Masahiro
Department Of Clinical Pharmacology And Therapeutics Ehime University Graduate School Of Medicine
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IWATA Shin-ichi
Department of Pharmacology, Faculty of Medicine, Kagoshima University
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Iwata Shin-ichi
Department Of Pharmacology Faculty Of Medicine Kagoshima University
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Nomoto Masahiro
Department Of Pharmacology Faculty Of Medicine Kagoshima University
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MITSUDA Minoru
Department of Pharmacology, Faculty of Medicine, Kagoshima University
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Mitsuda Minoru
Department Of Pharmacology Faculty Of Medicine Kagoshima University
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