Pramipexole Upregulates Dopamine Receptor D<SUB>2</SUB> and D<SUB>3</SUB> Expression in Rat Striatum
スポンサーリンク
概要
- 論文の詳細を見る
Randomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson’s disease. We investigated the comparative efficacy of pramipexole toward dopamine receptor D<SUB>2</SUB> and D<SUB>3</SUB> expression in rat brain. Groups of rats were treated subacutely with pramipexole (1 mg/kg), imipramine (10 mg/kg), or bromocriptine (5 mg/kg), with appropriate controls. Using real-time RT-PCR and immunoblotting, dopamine receptor D<SUB>2</SUB> and D<SUB>3</SUB> expression was up-regulated in the striatum following pramipexole treatment, while imipramine and bromocriptine had no significant effects. These findings support that pramipexole exerts additional therapeutic benefits such as decreasing depression by increasing dopamine receptor D<SUB>3</SUB> expression in the striatum.
- 公益社団法人 日本薬理学会の論文
著者
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Nomoto Masahiro
Department Of Clinical Pharmacology And Therapeutics Ehime University Graduate School Of Medicine
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Nishikawa Noriko
Department Of Therapeutic Medicine Ehime University Graduate School Of Medicine
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Nishikawa Noriko
Department Of Medicine Azumi General Hospital
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Nagai Masahiro
Department Of Biodesign Division Of Biosystems Institute Of Biomaterials And Bioengineering Tokyo Me
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Tokunaga Naohito
Department Of Biology And Earth Sciences Faculty Of Science Ehime University
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Choudhury Mohammed
Department Of Therapeutic Medicine Ehime University Graduate School Of Medicine
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Tujii Tomoaki
Department of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Japan
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Iwaki Hirotaka
Department of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Japan
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Kaneta Mika
Department of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Japan
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Nomoto Masahiro
Department of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Japan
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Nishikawa Noriko
Department of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Japan
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Tokunaga Naohito
Department of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Japan
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