Indomethacin Decreases Arachidonic Acid Uptake in HCA-7 Human Colon Cancer Cells
スポンサーリンク
概要
- 論文の詳細を見る
Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal cancer. However, evidence is accumulating that NSAIDs have anti-cancer effects in addition to inhibiting cyclooxygenase (COX)-mediated prostanoid biosynthesis. We now show that indomethacin, a popular NSAID, significantly reduced the [3H]-arachidonic acid uptake in HCA-7 human colon cancer cells. Interestingly, no decrease in the uptake of [3H]-arachidonic acid occurred when the cells were treated with aspirin, diclofenac, and sulindac even though the concentrations of these NSAIDs were high enough to inhibit COX-2 activity. These findings suggest that indomethacin has a novel anti-cancer effect that may be independent of COX-2 inhibition.
- 社団法人 日本薬理学会の論文
- 2008-11-20
著者
-
FUJINO Hiromichi
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
-
MURAYAMA Toshihiko
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
-
KAWASHIMA Tatsuo
Department of Internal Medicine, Toho University Sakura Medical Center
-
Fujino Hiromichi
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Fujino Hiromichi
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Hokkaido University:(present A
-
Murayama T
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Murayama Toshihiko
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Murayama Toshihiko
Laboratory Of Chemical Pharamacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Murayama Toshihiko
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ. Jpn
-
TOYOMURA Kaori
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
-
ORIDO Takashi
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
-
HASEGAWA Yuta
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
-
Hasegawa Yuta
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Kurosawa Takeshi
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ. Jpn
-
Toyomura Kaori
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Orido Takashi
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
-
Kawashima Tatsuo
Department Of Internal Medicine Toho University School Of Medicine Sakura Hospital
関連論文
- Effects of Synthetic Sphingosine-1-Phosphate Analogs on Cytosolic Phospholipase A2α–Independent Release of Arachidonic Acid and Cell Toxicity in L929 Fibrosarcoma Cells: the Structure–Activity Relationship
- Activation of Cytosolic Phospholipase A_2α by Epidermal Growth Factor (EGF) and Phorbol Ester in HeLa Cells : Different Effects of Inhibitors for EGF Receptor, Protein Kinase C, Src, and C-Raf
- Effects of Synthetic Sphingosine-1-Phosphate Analogs on Cytosolic Phospholipase A_2α-Independent Release of Arachidonic Acid and Cell Toxicity in L929 Fibrosarcoma Cells : the Structure-Activity Relationship
- Activation of Cytosolic Phospholipase A2α by Epidermal Growth Factor (EGF) and Phorbol Ester in HeLa Cells: Different Effects of Inhibitors for EGF Receptor, Protein Kinase C, Src, and C-Raf
- Depressive Behavior and Alterations in Receptors for Dopamine and 5-Hydroxytryptamine in the Brain of the Senescence Accelerated Mouse (SAM)-P10
- Role of Galectin-3 in Human Pulmonary Fibrosis
- Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway
- Development of an Enzyme-Linked Immunosorbent Assay System to Determine the Presence of Antibodies Specific for Taxane Structures
- Possible Role of Interleukin-6 in PC12 Cell Death Induced by MPP^+ and Tetrahydroisoquinoline
- Determination of the Functional Domain of a Mouse Autonomous Replicating Sequence
- Expression of Cytosolic Phospholipase A_2α in Murine C12 Cells, a Variant of L929 Cells, Induces Arachidonic Acid Release in Response to Phorbol Myristate Acetate and Ca^ Ionophores, but Not to Tumor Necrosis Factor-α
- Extracellular Signal Regulated Protein Kinase and c-Jun N-Terminal Kinase are Involved in m1 Muscarinic Receptor-Enhanced Interleukin-2 Production Pathway in Jurkat Cells
- Nicotine-Induced Neurogenic Relaxation in the Mouse Colon : Changes With Dextran Sodium Sulfate-Induced Colitis
- Indomethacin Decreases Arachidonic Acid Uptake in HCA-7 Human Colon Cancer Cells
- Enhancement of Phenylephrine-Induced Contraction in the Isolated Rat Aorta With Endothelium by H_2O-Extract From an Oriental Medicinal Plant Leonuri herba
- Increases in plasma concentration of progesterone by protease-sensitive urinary pheromones in female rats
- Lafutidine-Induced Increase in Intracellular Ca^ Concentrations in PC12 and Endothelial Cells
- Mediastinal Lymphadenopathy without Cervical Lymphadenopathy in a Case of Kikuchi- Fujimoto Disease
- Expression of TNF-related Apoptosis-inducing Ligand (TRAIL) and TRAIL Receptor 1 on Cancer and Normal Tissues in Patients with Non-small Cell Lung Cancer
- Vosorelaxing Effect of Mesaconitine, an Alkaloid From Aconitum japonicum, on Rat Small Gastric Artery : Possible Involvement of Endothelium-Derived Hyperpolarizing Factor
- Quercetin-Induced PC12 Cell Death Accompanied by Caspase-Mediated DNA Fragmentation(Pharmacology)
- Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of κ-Opioid Receptor, in Urethane-Anesthetized Rats
- Lafutidine-Induced Increase in Intracellular Ca2+ Concentrations in PC12 and Endothelial Cells
- Modifications of Capsaicin-Sensitive Neurons in Isolated Guinea Pig Ileum by [6]-Gingerol and Lafutidine
- Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
- Regulatory Mechanism and Physiological Role of Cytosolic Phospholipase A_2(Diversity of Phospholipase A_2 Enzymes)
- Nicotine-Induced Neurogenic Relaxation in the Mouse Colon: Changes With Dextran Sodium Sulfate–Induced Colitis
- Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase-Mediated Pathway
- Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-β1-induced expression of α-smooth muscle actin in human fetal lung fibroblasts
- Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain
- Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells
- Impaired Consciousness Caused by a Metastatic Adrenal Tumor of Pulmonary Adenocarcinoma
- Expression of Cytosolic Phospholipase A2.ALPHA. in Murine C12 Cells, a Variant of L929 Cells, Induces Arachidonic Acid Release in Response to Phorbol Myristate Acetate and Ca2+ Ionophores, but Not to Tumor Necrosis Factor-.ALPHA.