Vosorelaxing Effect of Mesaconitine, an Alkaloid From Aconitum japonicum, on Rat Small Gastric Artery : Possible Involvement of Endothelium-Derived Hyperpolarizing Factor

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概要

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• Aconiti tuber, roots of aconite (Aconitum japonicum), has been used for centuries in Japan and China to increase peripheral body temperature. We previously reported that mesaconitine, an alkaloid from Aconitum japonicum, elicits endothelium-dependent and nitric oxide-mediated relaxation in isolated rat aorta. In the present study, we investigated the effect of mesaconitine on isolated rat small gastric arteries. Mesaconitine elicited a concentration-dependent (10, 30, 100 μM) vasorelaxation in isolated rat gastric artery precontracted with norepinephrine, which was resistant to Nω-nitro-<sc>L</sc>-arginine (<sc>L</sc>-NNA) (an inhibitor of nitric oxide synthase) and indomethacin (an inhibitor of cyclooxygenase). The <sc>L</sc>-NNA- and indomethacin-resistant relaxation by mesaconitine was mainly endothelium-dependent, inhibited by high K+ (30 mM), and inhibited by a combination of Ca2+-dependent K+ channel blockers, charybdotoxin and apamin. The relaxation by mesaconitine was proportional to the external Ca2+ concentration. These results suggest that mesaconitine elicits vasorelaxation of isolated rat small gastric artery mainly via release of endothelium-derived hyperpolarizing factor.

• 社団法人 日本薬理学会の論文
• 2002-08-01

著者

• Van De

  Department Of Analytical Chemistry Free University

• Murayama Toshihiko

  Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Science Chiba University

• Murayama Toshihiko

  Laboratory Of Chemical Pharamacology Graduate School Of Pharmaceutical Sciences Chiba University

• Mitamura M

  Department Of Physiology And Physiopathology Ghent University

• Horie Shunji

  Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Science Chiba University

• MITAMURA Mana

  Department of Physiology and Physiopathology, Ghent University

• BOUSSERY Koen

  Department of Physiology and Physiopathology, Ghent University

• Boussery Koen

  Department Of Physiology And Physiopathology Ghent University

• Mitamura Mana

  Department Of Physiology And Physiopathology Ghent University

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