^<13>C-Acetic Acid Is More Sensitive Than ^<13>C-Octanoic Acid for Evaluating Gastric Emptying of Liquid Enteral Nutrient Formula by Breath Test in Conscious Rats(Pharmacology)

概要

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Breath test using ^<13>C-labeled compound has been used as a convenient method to evaluate gastric emptying. ^<13>C-Labeled acetic acid or octanoic acid has been used in clinic. However, there is few report comparing two compounds. This study aimed to compare ^<13>C-acetic acid and ^<13>C-octanoic acid in newly-constituted breath test for monitoring gastric emptying in conscious rats. After fasting, rats were orally administered Racol (liquid enteral nutrient formula) containing ^<13>C-labeled compound (same molar of ^<13>C-acetic acid or ^<13>C-octanoic acid) and housed in a chamber. The expired air in the chamber was collected in a breath-sampling bag using a tube and aspiration pump. The level of ^<13>CO_2 in the expired air was measured using an infrared spectrometer at appropriate intervals for 120 min. Expired ^<13>CO_2 air from ^<13>C-acetic acid changed at significantly higher levels than that from ^<13>C-octanoic acid. C_<max> and AUC_<120min> values of expired ^<13>CO_2 from ^<13>C-acetic acid were significantly higher than those from ^<13>C-octanoic acid, but T_<max> was not different between them. These results show that ^<13>C-acetic acid is more sensitive for monitoring gastric emptying than ^<13>C-octanoic acid in liquid test meal although both acids clearly monitored gastric emptying.
公益社団法人日本薬学会の論文
2007-03-01