Non-invasive Method for Evaluation of Gastrocecal Transit Time by Using a Breath Test in Conscious Rats
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概要
- 論文の詳細を見る
The aim of this study was to establish a method for evaluating gastrocecal transit time using a simple and noninvasive 13C-breath-test system in conscious rats. After fasting, rats were orally administered lactose-[13C]ureide. 13CO2 level in the expired air was measured at appropriate intervals. It was confirmed that priming dose of lactose-ureide was necessary for determining gastrocecal transit time. The level of 13CO2 in the expired air increased in a lactose-[13C]ureide concentration–dependent manner. The gastrocecal transit time determined with 30 mg/kg of lactose-[13C]ureide was 160 ± 24.5 min. This method is expected to contribute to the further understanding of intestinal pathophysiology.
- 社団法人 日本薬理学会の論文
- 2009-06-20
著者
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Yoshida Kaori
Food Sci. Inst. Div. Of Res. And Dev. Meiji Dairies Corp. Jpn
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Uchida Masayuki
Food Functionality Research Institute Division Of Research And Development Meiji Dairies Corporation
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