An Improved and Reliable Method for the Induction of Colitis in Rats Using 2,4,6-Trinitrobenzene Sulfonic Acid
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概要
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We performed this study to develop a reliable method for inducing colitis in rats using 2,4,6-trinitrobenzene sulfonic acid (TNBS) to reduce the variation in ulcer size. A pair of ring forceps was used to clamp the colon and 0.1 M TNBS in ethanol was injected into the luminal side of the clamped portion. This method resulted in a small coefficient of variation of the ulcer index. A significant linearity was observed by plotting ulcer size against days after ulcer induction in both logarithm scales. These findings show that this technique is simple and reliable and that ulcers heal linearly.
- 社団法人 日本薬理学会の論文
- 2005-02-20
著者
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MOGAMI Orie
Food Functionality Research Institute, Division of Research and Development, Meiji Dairies Corporati
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Mogami Orie
Food Science Institute Division Of Research And Development Meiji Dairies Corporation
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Uchida Masayuki
Food Functionality Research Institute Division Of Research And Development Meiji Dairies Corporation
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Uchida Masayuki
明治乳業研究本部食機能科学研究所
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Mogami Orie
Food Sci. Inst. Div. Of Res. And Dev. Meiji Corp. Ltd. Jpn
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