Novel Dipeptidyl Peptidase-4–Inhibiting Peptide Derived From β-Lactoglobulin
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概要
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Trypsin-treated β-lactoglobulin significantly decreased the glucose level after an oral glucose tolerance test using mice. We performed the present study to identify the active peptide inhibiting dipeptidyl peptidase-4 from trypsin-treated β-lactoglobulin. Trypsin-treated β-lactoglobulin showed a concentration-dependent inhibition for dipeptidyl peptidase-4, with an IC50 value of 210 μM, although non-treated β-lactoglobulin showed no significant effect in the in vitro assay. The active peptide was isolated from trypsin-treated β-lactoglobulin and identified as the hexapeptide Val-Ala-Gly-Thr-Trp-Tyr (β-lactoglobulin f15-20). This hexapeptide also exhibited a concentration-dependent inhibitory effect and IC50 value was 174 μM, suggesting that this hexapeptide is almost totally responsible for the DPP-4 inhibitory activity of trypsin-treated β-lactoglobulin.
著者
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MOGAMI Orie
Food Functionality Research Institute, Division of Research and Development, Meiji Dairies Corporati
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Uchida Masayuki
Food Functionality Research Institute Division Of Research And Development Meiji Dairies Corporation
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Ohshiba Yukio
Food Science Institute Division Of Research And Development Meiji Corporation Ltd.
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Mogami Orie
Food Science Institute Division Of Research And Development Meiji Corporation Ltd.
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