Involvement of Nitric Oxide From Nerves on Diarrhea Induced by Castor Oil in Rats
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概要
- 論文の詳細を見る
Nitric oxide(NO)is involved in the mechanism of castor oil-induced diarrhea.This study was performed to elucidate the source of NO.Diarrhea was induced by oral administration of castor oil in rats.Diarrhea was significantly inhibited by the pre-treatment with a relatively selective nerve NO synthase inhibitor, 7-nitroindazole.This effect was attenuated by the treatment with L-arginine.Capsaicin-sensitive afferent nerve degeneration did not affect the diarrhea.NG-Nitro-L-arginine methylester significantly inhibited diarrhea even in capsaicin-pretreated rats.These data suggest, a least in part, the involvement of NO from nerves on the diarrhea induced by castor oil in rats.
- 社団法人 日本薬理学会の論文
- 2000-02-01
著者
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Uchida Masayuki
Food Functionality Research Institute Meiji Milk Products Co. Ltd.
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Uchida Masayuki
Meiji Dairies Co.
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Uchida M
Food Functionality Research Institute Meiji Milk Products Co. Ltd.
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YAMATO Shigeru
International Medical Center of Japan
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KATO Yumi
Meiji Institute of Health Science
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MATSUEDA Kei
International Medical Center, Internal Medicine, Division of Gastoroenterology
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SHODA Ryousuke
International Medical Center, Internal Medicine, Division of Gastoroenterology
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MURAOKA Akira
International Medical Center, Internal Medicine, Division of Gastoroenterology
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Shoda Ryosuke
Division Of Gastroenterology Internal Medicine International Medical Center
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MURAOKA Akira
Division of Gastroenterology, Internal Medicine, International Medical Center
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YAMATO Shigeru
Division of Gastroenterology, Internal Medicine, International Medical Center
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Muraoka Akira
Division Of Gastroenterology Internal Medicine International Medical Center
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Yamato Shigeru
Division Of Gastroenterology Internal Medicine International Medical Center
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