D-1 type of dopamine autoreceptors are not involved in the regulation of dopamine synthesis in the striatum.
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概要
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To clarify if dopamine (DA) synthesis is regulated by D-1 DA receptors located on dopaminergic nerve terminals in the striatum, we investigated effects of D-1 DA receptor agonist and antagonist on striatal 3, 4-dihydroxyphenylalanine (DOPA) accumulation induced by γ-butyrolactone in mice treated with an amino acid decarboxylase inhibitor. SKF 38393, a D-1 agonist, did not affect DOPA accumulation, whereas apomorphine that stimulates both D-1 and D-2 receptors inhibited the accumulation. SCH 23390, a D-1 antagonist, did not antagonize apomorphine-induced inhibition of DOPA accumulation, while YM-091 51-2, a D-2 antagonist, reversed it. These results suggest that D-1 type of DA autoreceptors is not involved in the inhibition of in vivo DA synthesis.
- 公益社団法人 日本薬理学会の論文
著者
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WATANABE Hiroshi
Research Group for Biotechnology Development, Japan Atomic Energy Research Institute (JAERI-Takasaki
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Suda Hiroshi
Research Laboratory Santen Pharmaceutical Co. Ltd.
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Nomura Yasuyuki
Research Information Center Institute Of Plasma Physics Nagoya University
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SEKIHARA Shun-ichi
Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
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NOMURA Yasuyuki
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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SUDA Hiroshi
Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
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- D-1 type of dopamine autoreceptors are not involved in the regulation of dopamine synthesis in the striatum.