Effects of a Carthami Flos Extract and Its Constituents on the Beating Amplitude of Cultured Myocardial Cell Sheets
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概要
- 論文の詳細を見る
In the course of our studies on naturally-occurring cardioactive substances, we found that a methanolic extract of Carthami Flos significantly stimulated the beating amplitiude of cultured myocardial cell sheets prepared from mouse embryo hearts but that the extract did not affect the beating rate of the sheets. By the bio-assay directed fractionation of the extract, seventeen compounds were isolated from ether-soluble and BuOH-soluble fractions that increased the beating amplitude. Of these compounds, scutellarein (1), 4-hydroxycinnamic acid (8), 3,4-dihydroxycinnamic acid (9), 6-hydroxykaempferol 3-glucoside (10) and quercetin 3,7-diglucoside (16), appreciably increased the beating amplitude but apigenin (3) decreased it. Since 6-hydroxykaempferol 3-glucoside (10) inhibited Na^+-K^+ ATPase activity, the positive inotropic effect on cultured myocardial cell sheets induced by 10 may be correlated with its enzyme inhibition.
- 日本生薬学会の論文
- 1992-09-20
著者
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicine) Toyama Medical And Pharmaceut
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Huang Xin-li
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Namba Tsuneo
Research Institute For Wakan-yaku (oriental Medicine) Toyama Medical And Pharmaceutical University
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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HATTORI MASAO
Research Institute for Wakan-Yaku (Oriental Medicines)
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