Muramyl dipeptide derivatives with multiprenylacetyl group. Synthesis and immunological activities.

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概要

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• Several linear and branched all-<I>trans</I>-multiprenylacetic acids were synthesised, and introduced to the 6 position of the sugar moiety of muramyl dipeptide and its analog, <I>via</I> an amino acid as a linking unit. Compared with the saturated stearoyl derivative, all the compounds having a multiprenylacetyl group exhibited more potent adjuvant activity on the induction of delayed-type hypersensitivity to <I>N</I>-acetyl-3-(4-arsonophenylazo)-L-tyrosine. The derivatives with larger branched side chains tended to have increased activity.

• 公益社団法人 日本化学会の論文

著者

• FUJINO Masahiko

  Central Research Division, Takeda Chemical Industries, Ltd.

• Shiba Tetsuo

  Department Of Chemistry Faculty Of Science Osaka University

• Fujino Masahiko

  Central Research Division Takeda Chemical Ind. Ltd.

• Terao Shinji

  Central Research Division Takeda Chemical Industries Ltd.

• Saiki Ikuo

  Institute Of Immunological Science Hokkaido University

• Azuma Ichiro

  Institute Of Immunological Cience

• YAMAMURA Yuichi

  Osaka University

• Terao Shinji

  Central Research Division, Takeda Chemical Industries, Ltd.

• Fukuda Tsunehiko

  Central Research Division, Takeda Chemical Industries, Ltd.

• Kobayashi Shigeru

  Central Research Division, Takeda Chemical Industries, Ltd.

• Yukimasa Hidefumi

  Central Research Division, Takeda Chemical Industries, Ltd.

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