Synthesis of 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with antitumor activity.
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概要
- 論文の詳細を見る
<I>N</I>-Acetylmuramyl-L-alanyl-D-isoglutamine corresponding to the minimum structure responsible for the immunoadjuvant activity of bacterial cell walls was acylated at the 6-hydroxyl group with various mycolic acids of long carbon chains in order to test their possible antitumor effects. Mycolic acids used were extracted from cell walls of <I>Mycobacterium</I>, <I>Nocardia</I>, and <I>Corynebacterium</I>. All the mycoloyl derivatives synthesized show antitumor activity based on a principle of immunotherapy.
- 公益社団法人 日本化学会の論文
著者
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Kusumoto Shoichi
Department Of Chemistry Faculty Of Science Osaka University
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Shiba Tetsuo
Department Of Chemistry Faculty Of Science Osaka University
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Okada Satoshi
Department Of Applied Chemistry And Biotechnology University Of Fukui
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YAMAMURA YUICHI
The Third Department of Internal Medicine, Medical School of Osaka University
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Azuma Ichiro
The Third Department of Internal Medicine, Medical School, Osaka University
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