Synthesis and stereochemistry of hypusine, a new amino acid in bovine brain.
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概要
- 論文の詳細を見る
Hypusine, a new basic amino acid occurring in the homogenate of bovine brain tissue, was synthesized to determine the absolute structure. <I>N</I><SUP>α</SUP>-Benzyloxycarbonyl-L-lysine benzyl ester was coupled with (<I>S</I>)- or (<I>R</I>)-4-benzyloxycarbonylamino-1-bromo-2-butanol derived from L- or D-malic acid, respectively. The products were deprotected by catalytic hydrogenation. One of the synthetic compounds, <I>i.e.</I>, (2<I>S</I>,9<I>R</I>)-2,11-diamino-9-hydroxy-7-azaundecanoic acid, was completely identical with natural hypusine in all respects.
- 公益社団法人 日本化学会の論文
著者
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Shiba Tetsuo
Department Of Chemistry Faculty Of Science Osaka University
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Wakamiya Tateaki
Department Of Chemistry Faculty Of Science Osaka University
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Okada Satoshi
Department Of Applied Chemistry And Biotechnology University Of Fukui
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Akiyama Hitoshi
Department Of Drug Metabolism Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Umeda Isao
Department of Chemistry, Faculty of Science, Osaka University
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