Chemical synthesis of N-acetylmuramyl peptides with partial structures of bacterial cell wall and their analogs in relation to immunoadjuvant activities.
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概要
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<I>N</I>-Acetylmuramyl peptides of successive length corresponding to the partial structures of cell wall in <I>Staphylococcus aureus</I> were synthesized in order to elucidate the minimum effective structure responsible for immunoadjuvant activity of bacterial cell walls. In view of the finding that <I>N</I>-acetylmuramyl-L-alanyl-D-isoglutamine was the least structure moiety for exhibition of the activity, nine analogs of either <I>N</I>-acetylmuramyl amino acid or <I>N</I>-acetylmuramyl dipeptide were also synthesized.
- 公益社団法人 日本化学会の論文
著者
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Ikenaka Kazuhiro
Department Of Chemistry Graduate School Of Science Osaka University
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Kusumoto Shoichi
Department Of Chemistry Faculty Of Science Osaka University
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Shiba Tetsuo
Department Of Chemistry Faculty Of Science Osaka University
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Tarumi Yuzo
Department of Chemistry, Faculty of Science, Osaka University
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