Synthesis of 6-O-acyl derivatives of immunoadjuvant active N-acetylmuramyl-L-alanyl-D-isoglutamine.
スポンサーリンク
概要
- 論文の詳細を見る
Seven acyl derivatives of <I>N</I>-acetylmuramyl-L-alanyl-D-isoglutamine, which had previously been shown to be a minimum structure required for the immunoadjuvant activity, were synthesized in order to evaluate the significance of lipophilicity on the adjuvant activity and on the possible antitumor effect. Among them, are included 6-<I>O</I>-docosanoyl, stearoyl, lauroyl, octanoyl, butyryl, acetyl, and 4,6-di-<I>O</I>-acetyl derivatives. Some of these compounds were found to serve an improvement in the administration method to living body.
- 公益社団法人 日本化学会の論文
著者
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Yamamoto Koji
Department of Internal Medicine, Hattori Memorial Hospital
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Kusumoto Shoichi
Department Of Chemistry Faculty Of Science Osaka University
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Shiba Tetsuo
Department Of Chemistry Faculty Of Science Osaka University
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Okada Satoshi
Department Of Applied Chemistry And Biotechnology University Of Fukui
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Yamamoto Koji
Department of Cardiology, Nagoya City University Medical School
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