Preparation of N-acetylmuramyl-L-[U-14C]alanyl-D-isoglutamine via a novel synthetic route.
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概要
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For the investigation on the action mechanism of immunoadjuvant active <I>N</I>-acetylmuramyl-L-alanyl-D-isoglutamine, its labeled compound, <I>i.e.,</I> <I>N</I>-acetylmuramyl-L-[U-<SUP>14</SUP><I>C</I>]alanyl-D-isoglutamine was synthesized. For this purpose, an entirely novel synthetic route for the muramyl dipeptide was exploited using cold materials and applied to the preparation of the labeled compound. A convenient synthetic procedure of isoglutamine derivatives is also described.
- 公益社団法人 日本化学会の論文
著者
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Ikenaka Kazuhiro
Department Of Chemistry Graduate School Of Science Osaka University
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Kusumoto Shoichi
Department Of Chemistry Faculty Of Science Osaka University
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Shiba Tetsuo
Department Of Chemistry Faculty Of Science Osaka University
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