Synthetic study on peptide antibiotic nisin. I. The synthesis of ring A.
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概要
- 論文の詳細を見る
Synthesis of the ring A, a cyclic sulfide peptide part containing dehydroalanine residue, in peptide antibiotic nisin was successfully achieved by applications of two novel procedures. First, a sulfide ring was derived from a cyclic disulfide peptide by desulfurization with P(Et<SUB>2</SUB>N)<SUB>3</SUB>. Secondly, for the preparation of dehydroalanyl residue, a simple and convenient method through Hofmann degradation of 2,3-diaminopropionyl residue was newly exploited in the presence of sulfide linkage.
- 公益社団法人 日本化学会の論文
著者
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Fukase Koichi
Department Of Chemistry Columbia University
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Shiba Tetsuo
Department Of Chemistry Faculty Of Science Osaka University
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Wakamiya Tateaki
Department Of Chemistry Faculty Of Science Osaka University
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Shimbo Kuniaki
Department of Chemistry, Faculty of Science, Osaka University
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Sano Akihiko
Department of Chemistry, Faculty of Science, Osaka University
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Fukase Koichi
Department of Chemistiy, Graduate School of Science, Osaka University
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