Chemical Studies on Tuberactinomycin. IX. Nuclear Magnetic Resonance Studies on Tuberactinomycins and Tuberactinamine N
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概要
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Conformational analyses of peptide antibiotics tuberactinomycins were performed by NMR spectroscopy of 100 MHz. Studies on temperature dependence and deuterium exchange in amide proton resonances revealed the presence of an intramolecular hydrogen bond participated with α-amide proton of the guanidino amino acid residue in the cyclic part of each molecule. The same result was obtained in tuberactinamine N, which is the cyclopeptide moiety without amino acid side chain in tuberactinomycins N and O. The common rigid structure fixed by hydrogen bonding in the cyclic part seems to be a requisite for the exhibition of microbial activity in tuberactinomycin family.
- 公益社団法人 日本化学会の論文
著者
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Shiba Tetsuo
Department Of Chemistry Faculty Of Science Osaka University
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Wakamiya Tateaki
Department Of Chemistry Faculty Of Science Osaka University
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