Synthesis and antitumor activity of N-acetylmuramyl-L-alanyl-D-isoglutamine 6-phosphate and its lipophilic derivatives.
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概要
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6-Phosphate of <I>N</I>-acetylmuramyl-L-alanyl-D-isoglutamine and its lipophilic derivatives, i.e., 6-(octadecyl hydrogenphosphate) and 6-(2-docosyltetracosyl hydrogenphosphate) were synthesized after the structural feature of mycobacterial cell walls for the purpose to modify and possibly to enhance the immunostimulating activity of the muramyl dipeptide which is the minimum requisite for the activity. As expected, the latter more lipophilic phosphate showed a high activity in a tumor regression test.
- 公益社団法人 日本化学会の論文
著者
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Kusumoto Shoichi
Department Of Chemistry Faculty Of Science Osaka University
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Shiba Tetsuo
Department Of Chemistry Faculty Of Science Osaka University
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IMOTO Masahiro
Department of Chemistry, Faculty of Science, Osaka University
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Tohgo Akiko
Research Institute, Daiichi Seiyaku Co., Ltd.
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Matsumoto Kensuke
Research Institute, Daiichi Seiyaku Co., Ltd.
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Kageyama Shigeki
Department of Chemistry, Faculty of Science, Osaka University
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Kohno Morihiro
Research Institute, Daiichi Seiyaku Co., Ltd.
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Hashimoto Shinjiro
Research Institute, Daiichi Seiyaku Co., Ltd.
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