Chemical Studies on Tuberactinomycin. VII. Synthesis of γ-Hydroxy-β-lysine

スポンサーリンク

概要

• 論文の詳細を見る

• γ-Hydroxy-β-lysine is a new basic amino acid isolated from the hydrolyzates of antitubercular peptides, tuberactinomycin A and N. In order to confirm the structure and establish the stereochemistry of the amino acid, two diastereoisomers of γ-hydroxy-DL-β-lysine were synthesized by Arndt-Eistert synthesis <I>via</I> β-hiydroxyornithine. Synthetic <I>erythro</I> and <I>threo</I> isomers were found to be identical spectroscopically and chromatographically with the corresponding forms obtained from the antibiotics respectively.

• 公益社団法人 日本化学会の論文

著者

• Shiba Tetsuo

  Department Of Chemistry Faculty Of Science Osaka University

• Wakamiya Tateaki

  Department Of Chemistry Faculty Of Science Osaka University

• Kaneko Takeo

  Department Of Cardiology National Fukuoka Higashi Medical Center

• Teshima Tadashi

  Department Of Chemistry Faculty Of Science Osaka University

• Kubota Ichiro

  Department of Chemistry, Faculty of Science, Osaka University

関連論文

• Detection of Subterranean Biosphere by Using Phosphatase Activity(Submarine Hydrothermal Systems, International Symposium on Origins of Life and Astrobiology)
• POSSIBLE FORMATION OF AMINO ACIDS PRECURSORS IN TITAN BY COSMIC RAYS(Mars and Titan, International Symposium on Origins of Life and Astrobiology)
• ROLES OF COSMIC RAYS IN CHEMICAL EVOLUTION TOWARD ORIGINS OF LIFE(Chemical Evolution, International Symposium on Origins of Life and Astrobiology)
• Formation and Stability of Complex Organic Compounds in Space Environments
• Detection of Biosphere Frontier by Using Phosphatase Activity
• Experimental verification of photostability for free- and bound-amino acids exposed to γ-rays and UV irradiation
• Evidence of the Hypsithermal Verified Using the Racemization Rate Constant of Amino Acids : An Estimation of Paleo-Ground Temperatures
• Pyrolysis of High-Molecular-Weight Complex Organics Synthesized from a Simulated Interstellar Gas Mixture Irradiated with 3 MeV Proton Beam
• Distribution of amino acid and its stereochemistry related with biological activities in Rikubetsu, Hokkaido, Japan
• Pyrolysis experiment of simulated exogenous complex organics synthesized from the gas mixtures of CO, NH_3, and H_2O by 3 MeV proton irradiation
• Formation of organic compounds from simulated Titan atmosphere : Perspectives of the Cassini mission
• Amino Acid Precursors from Carbon Monoxide in Simulated Interstellar Dust Ice Mantle by UV Irradiation at 10K
• Formation of Amino Acids from Possible Interstellar Media by γ-rays and UV Irradiation
• Abiotic Formation of Bioorganic Compounds in Space -Preliminary Experiments on Ground and Future Exobiology Experiments in Space-
• Formation of Organic Compounds in Simulated lnterstellar Media with High Energy Particles
• Study on Ethanol-Water Clusters in Gas and Liquid Phases by Liquid Ionization Mass Spectrometry (BMS特集号)
• Characterization of Oligomers by Liquid Ionization Mass Spectrometry. Photopolymerization Process of p-Phenylene Diacrylic Acid Diethyl Ester Crystal
• Water-Etha nol Clusters at the Liquid Surface under Atmospheric Pressure Observed by Liquid Ionization Mass Spectrometry
• Purification and Characterization of [^3H] Mepyramine (Histamine H_1 Antagonist)-Binding Protein from Rat Liver: A Highly Homologous Protein with Cytochrome P450 2D
• ＜Poster＞Synthesis of 2-NBDLG, the antipode of fluorescent D-glucose tracer 2-NBDG
• ＜Symposium I＞A new imaging method of glucose transport in live cells
• Design and Synthesis of Peptides Passing through the Blood-Brain Barrier
• Emphysematous Cystitis with Venous Bubbles
• Enzyme Flexibility : A New Concept in Recognition of Hydrophobic Substrates^1
• PC87 SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF BULGECIN A
• Syntheses of Stem Peptides of Bacterial Cell Walls with Proinflammatory Activity
• An Efficient Procedure for Synthesis of Phosphopeptides through the Benzyl Phosphate-Protection by the Boc Mode Solid-Phase Method
• Preparations of N^α-Fmoc-0-[(Benzyloxy)hydroxyphosphinyl] β-Hydroxy α-Amino Acid Derivatives
• Preparation of Phosphoamino Acid Derivatives with Acid Stable O-Phosphono-Protection for the Boc-Mode Solid-Phase Synthesis of Phosphopeptides^
• An Efficient Procedure for Solid-Phase Synthesis of Phosphopeptides by the Fmoc Strategy
• MECHANISM OF INHIBITION OF CASPASE-3 ACTIVITY IN STARFISH UNFERTILIZED EGGS(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• CASPASE-3 INHIBITOR IN STARFISH IMMATURE OOCYTES(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• QUANTIFICATION OFIN VIVO CASPASE-3 ACTIVITY IN AN APOPTOTIC STARFISH EGG USING MEMBRANE-IMPERMEANT SUBSTRATE(Developmental Biology)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
• Synthesis of O-Linked β-N-Acetylglucosamine-Containing Peptides by the Boc Strategy Employing the HF Procedure for Final Deprotection
• SOLID PHASE SYNTHESIS OF THE ANTIBACTERIAL GLYCOPEPTIDE, FORMAECIN USING BOC-STRATEGY
• PC77 TOTAL SYNTHESIS OF SPIDER TOXIN, NSTX-3 AND ITS STRUCTURE-ACTIVITY RELATIONSHIP
• Construction of a Supercritical Water flow Reactor to Simulate the Submarine Hydrothermal System
• Strecker-type reactions by using a supercritical water flow reactor simulating submarine hydrothermal systems
• Reaction of Amino Acids in a Supercritical Water-Flow Reactor Simulating Submarine Hydrothermal Systems
• Liquid Ionization Mass Spectrometry of Some Triorganotin Carboxylates
• Chemical Knowledge and View for Natural Substances and Industrial Products : Approach from Familiar Materials of Everyday Life
• How good is QT dispersion as an index of the inhomogeneity of repolarization in in-situ porcine hearts?
• Solid Phase Synthesis of Glycopeptide Using Boc-Strategy
• Improved Synthetic Method of Nephritogenic Glycopeptide, Nephritogenoside
• The Stereochemistry of Deoxynupharidine: The Absolute Configuration of Deoxynupharidine
• Studies on Peptides. VIII. The Synthesis of α,γ-Glutamyl Peptides and the Cleavage Reactions of their γ-Glutamyl Peptide Linkages
• Chemical studies on tuberactinomycin. XI. Semisyntheses of tuberactinomycin analogs with various amino acids in branched part.
• Muramyl dipeptide derivatives with multiprenylacetyl group. Synthesis and immunological activities.
• Syntheses and Properties of 2-Oxothiazolidine-4-carboxylic Acid and Its Derivatives
• Chemical synthesis of a biosynthetic precursor of lipid A with a phosphorylated tetraacyl disaccharide structure.
• Synthesis and antitumor activity of N-acetylmuramyl-L-alanyl-D-isoglutamine 6-phosphate and its lipophilic derivatives.
• Synthetic Studies of Bacitracin. VIII. Synthesis of Cyclohexapeptide Moiety
• Computer Simulation of the Growth of Ni on a Ni(111) Surface
• The structure of galantinamic acid, a new amino acid in a peptide antibiotic galantin I.
• Chemical Studies on Tuberactinomycin. V. Structures of Guanidino Amino Acids in Tuberactinomycins
• Chemical Studies on Tuberactinomycin. IX. Nuclear Magnetic Resonance Studies on Tuberactinomycins and Tuberactinamine N
• Chemical studies on tuberactinomycin. XIV. Novel synthesis of DL-capreomycidine.
• An improved synthesis of threo-3-methyl-D-cysteine.
• Synthetic study on peptide antibiotic nisin. III. Synthesis of ring C.
• Syntheses of four stereoisomers of .BETA.-methyllanthionine.
• Structural and stereochemical study of galantinic acid, a new amino acid from peptide antibiotic galantin I.
• The Novel Synthesis of Two Diastereomers of γ-Hydroxyproline
• Synthetic Studies of Bacitracin. VI. Synthesis of Unprotected Thiazoline Peptides
• Asymmetric Reduction of Some Dehydrophenylalanyl Peptides
• Synthetic Studies on Bacitracin. VII. Isomerization of Amino Acid Components of Thiazoline Peptides
• Chemical Studies on Tuberactinomycin. VII. Synthesis of γ-Hydroxy-β-lysine
• Synthetic Studies of Bacitracin. IX. Synthesis of Peptide Fragments for Bacitracins of Cycloheptapeptide Formula
• Synthesis and stereochemistry of hypusine, a new amino acid in bovine brain.
• Synthesis of alanyl-1-aminoethanesulfonic acid.
• Synthesis of 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with antitumor activity.
• Synthetic study on peptide antibiotic nisin. I. The synthesis of ring A.
• 4-Azidobutyryl group for temporary protection of hydroxyl functions.
• Total synthesis of Escherichia coli lipid A, the endotoxically active principle of cell-surface lipopolysaccharide.
• Synthesis of Acyl Derivatives of β-Lysine for Peptide Synthesis
• Synthesis of L-epicapreomycidine.
• Chemical studies on tuberactinomycin. XVII. Synthesis of threo-.GAMMA.-hydroxy-L-.BETA.-lysine, constituent amino acid of tuberactinomycin A and N.
• Preparation of N-acetylmuramyl-L-[U-14C]alanyl-D-isoglutamine via a novel synthetic route.
• Synthesis of 6-O-acyl derivatives of immunoadjuvant active N-acetylmuramyl-L-alanyl-D-isoglutamine.
• Racemization of Amino Acid Residues Fused in Thiazoline, Oxazoline, and Imidazoline Rings
• Syntheses of several muramyl peptides in relation to chemical structures of less immunoadjuvant bacterial cell walls.
• Chemical synthesis of N-acetylmuramyl peptides with partial structures of bacterial cell wall and their analogs in relation to immunoadjuvant activities.
• Synthesis of Streptolidine (Roseonine, Geamine)
• Component Amino Acids of the Antibiotic Longicatenamycin. Isolation of 5-Chloro-D-tryptophan
• Synthesis of Allyl 3-Deoxy-D-manno-2-octulopyranosidic Acid 4- and 5-Phosphates.
• Total synthesis of lipid A, active principle of bacterial endotoxin.
• Synthesis of threo-3-methylcysteine from threonine.

もっと見る 閉じる

スポンサーリンク