Synthetic Studies of Bacitracin. IX. Synthesis of Peptide Fragments for Bacitracins of Cycloheptapeptide Formula
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概要
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In the synthetic study of bacitracins, peptide fragments corresponding to a branched part of bacitracin F, <I>i.e.</I>, (<I>S</I>)-2-(2-methylbutyryl)thiazole-4-carboxylic acid 1-succinimidyl ester (III) and L-leucyl-γ-<I>t</I>-butyl-D-glutamyl-L-isoleucine (IV), were prepared. As a macrocyclic part of bacitracin A and F of cycloheptapeptide formula, cyclo- (<I>N</I><SUP>α</SUP>-benzyloxycarbonyl-L-lysyl-<I>N</I><SUP>δ</SUP>-cyclopentyloxycarbonyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-β-benzyl-D-aspartyl-L-asparaginyl) (V) was synthesized through cyanomethyl ester method.
- 公益社団法人 日本化学会の論文
著者
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Shiba Tetsuo
Department Of Chemistry Faculty Of Science Osaka University
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Kaneko Takeo
Department Of Cardiology National Fukuoka Higashi Medical Center
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MUNEKATA Eisuke
Department of Neurology, Institute of Clinical Medicine, and Institute of Applied Biochemistry, University of Tsukuba
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