The Suppressing Effect of the Extract from Cassia nomame on Clastogenicity and Cytotoxicity of Mitomycin C in CHO Cells
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概要
- 論文の詳細を見る
Chinese hamster ovary (CHO) K1 cells were treated with 2.5 μM Mitomycin C (MMC) for one hour and incubated in Ham's F12 medium containing 10% fetal bovine serum or in the medium supplemented with the extract from Cassia nomame pods, leaves and stems. The frequency of cells with chromosome aberrations was significantly lowered by the extract. Proliferation of CHO cells was suppressed by a 1-hr MMC treatment, but the suppression was nullified by the presence of the extract. These findings suggest that the extract can prevent the physiological damage caused by MMC.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
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Yamamoto Koji
Department of Internal Medicine, Hattori Memorial Hospital
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Takahara Yoshinori
Nagaoka University Of Technology
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Takahara Yoshinori
長岡技術科学大学生物系応用植物工学研究室
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Takahara Yoshinori
Department Of Bioengineering Nagaoka University Of Technology
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門脇 慎一
長岡技術科学大学生物系応用植物工学研究室
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Yamamoto Koji
Department Of Life Science Aichi University Of Education
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NAITOU Kazufumi
Department of Bioengineering, Nagaoka University of Technology
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NAITOU Kazufumi
長岡技術科学大学生物系応用植物工学研究室
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Yamamoto K
長岡技術科学大学生物系応用植物工学研究室
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Yamamoto Koji
Department of Cardiology, Nagoya City University Medical School
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