Long-Term Suppressive Effect of Octreotide on Progression of Metastatic Gastrinoma with Multiple Endocrine Neoplasia Type 1: Seven-Year Follow up
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概要
- 論文の詳細を見る
A 30-year-old woman had a history of prolactinoma and primary hyperparathyroidism. She was diagnosed as having multiple endocrine neoplasia type 1 with gastrinoma and liver metastases. Octreotide therapy was started and the serum gastrin level decreased immediately. Octreotide continued to suppress gastrin secretion over the next 7 years. The Ki67/MIB1 proliferation index of this tumor was only 0.5 % and somatostatin receptor (SSTR) 2 expression was very strong in both 2002 and 2009. This case suggests the importance of investigating the Ki67/MIB1 index and SSTR expression in patients with metastatic gastrinoma.
著者
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Matsuzawa Yuji
Department of Internal Medicine, Sumitomo Hospital
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Yamamoto Koji
Department of Internal Medicine, Hattori Memorial Hospital
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Tamba Sachiko
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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HOSHIDA Yoshihiko
Department of Pathology, Osaka University Graduate School of Medicine
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Yamaguchi Megu
Department of Endocrinology and Metabolism, Sumitomo Hospital
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Yamada Yuya
Department of Endocrinology and Metabolism, Sumitomo Hospital
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Hosokawa Yoshiya
Department of Endocrinology and Metabolism, Sumitomo Hospital
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Iwamoto Ryuya
Department of Endocrinology and Metabolism, Sumitomo Hospital
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Ihara Arisa
Department of Endocrinology and Metabolism, Sumitomo Hospital
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