Clinical Significance of High-Molecular Weight Form of Adiponectin in Male Patients With Coronary Artery Disease
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概要
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Background It has been reported previously that the measurement of plasma total adiponectin level is clinically useful to estimate the risk of coronary artery disease (CAD). Here, the relevance of high molecular weight (HMW) adiponectin with risk factors for atherosclerosis is investigated Methods and Results A total of 186 consecutive male CAD patients participated in the study and were categorized into quartiles based on their total adiponectin level. The interquartile cut-off points were 4.0, 5.5 and 7.0μg/ml. The HMW adiponectin levels were significantly lower in the quartile of lower total adiponectin levels both in non-diabetic and diabetic patients. In contrast, low molecular weight adiponectin levels (which were calculated as the Total-HMW) were constant. In univariate analysis, total adiponectin correlated negatively with body mass index and hemoglobin (Hb) A_<1c>, and HMW adiponectin correlated negatively with HbA_<1c> in nondiabetic patients. On the other hand, total and HMW adiponectin correlated positively with high-density lipoprotein-cholesterol (HDL-C) in diabetic patients. Multiple regression analysis revealed that HMW adiponectin correlated negatively with HbA_<1c> in non-diabetic patients, and total and HMW adiponectin correlated positively with HDL-C in diabetic patients. Conclusions Change in the HMW isoform reflects a change in total adiponectin level. Measurement of total and HMW adiponectin were equally useful in assessing metabolic risk in CAD patients.
- 社団法人日本循環器学会の論文
- 2007-12-20
著者
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MATSUZAWA Yuji
Sumitomo Hospital
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OKAMOTO Yoshihisa
Department of Bioregulation, Nippon Medical School
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Matsuzawa Yuji
Department of Internal Medicine, Sumitomo Hospital
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Shimomura Iichiro
Department of Metabolic Medicine, Osaka University Graduate School of Medicine
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Funahashi Tohru
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
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Kihara Shinji
Department of Metabolic Medicine, Osaka University
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Komura Noriyuki
Department of Metabolic Medicine, Graduate School of Medicine
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Nakagawa Yasuhiko
Department of Metabolic Medicine, Graduate School of Medicine
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Fujita Koichi
Department of Metabolic Medicine, Graduate School of Medicine
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Funahashi Tohru
Department of Metabolic Medicine, Graduate School of Medicine
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Kumada Masahiro
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
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Arita Yukio
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
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Sumitsuji Satoru
Department of Cardiology, Rinku General Medical Center
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Kawamoto Toshiharu
Department of Cardiology, National Hospital Kure Medical Center
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Nakagawa Yasuhiko
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Kihara Shinji
Department Of Metabolic Medicine Osaka University Graduate School Of Medicine
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Kubo Masaharu
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Koseki Masahiro
大阪大学 医学系研究科循環器内科学
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Mizuno Yuji
Division Of Cardiology Kumamoto Aging Research Institute
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Kawase Miyako
大阪大学 医学系研究科循環器内科学
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Funahashi Tohru
理化学研究所ゲノム医科学研究センター 内分泌･代謝疾患チーム
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Funahashi Tohru
熊本大学 医学薬学研究部循環器病態学
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Funahashi Tohru
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Ohara Takahiro
Cardiovascular Division of Medicine
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Kubo Masaharu
Department Of Cardiology Osaka University
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Yamagishi Masakazu
Sumitomo Hospital
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Matsuzawa Y
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Kumada Masahiro
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Kikuya Masahiro
東北大学 臨床薬学
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Kikuya Masahiro
New Industry Creation Hatchery Center Tohoku University
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Kikuya Masahiro
The Second Department Of Medicine Tohoku University Graduate School Of Pharmaceutical Science And Me
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Tamba Sachiko
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Arita Yukio
Department Of Cardiology Sumitomo Hospital
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Kawata Sumio
Department Of Gastroenterology Faculty Of Medicine Yamagata University
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Kawata S
Second Department Of Internal Medicine Yamagata University School Of Medicine
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Sumitsuji Satoru
Cardiology Of Heart Center Nozaki Tokushukai Hospital
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Sumitsuji Satoru
Department Of Cardiology Tokushukai Nozaki Hospital
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Sumitsuji Satoru
Department Of Cardiology Nozaki Tokushukai Hospital
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Sumitsuji Satoru
Department Of Advanced Cardiovascular Therapeutics Osaka University:heart Center Tokushukai Hospital
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Hayashi Noriyuki
Department Of Gastroenterology And Hepatology Osaka University Graduate School Of Medicine
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Koseki Masahiro
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Kihara Shinji
Department Of Gastroenterology And Hepatology Osaka University Graduate School Of Medicine
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Kihara Shinji
大阪大学 医学系研究科消化器内科学
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Sonoda Mina
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Hiuge Aki
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Okada Takuya
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Kuroda Yohei
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Matsumoto Satoru
Toyonaka Municipal Hospital
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Ouchi Noriyuki
Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine
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Kiso Shinichi
Second Department Of Internal Medicine Osaka University Medical School
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Kubota Shinji
大阪大学 医学系研究科消化器内科学
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Tamura Shinji
大阪大学 医学系研究科消化器内科学
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Tamba Sachiko
Minoh Municipal Hospital
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Okamoto Yoshihisa
Department Of Cardiovascular Medicine Brigham And Women's Hospital Harvard Medical School
-
Fujisawa Toshio
Division Of Gastroenterology Yokohama City University School Of Medicine
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Fujisawa Toshio
横浜市立大学 医学部消化器内科学
-
Tsuji Shingo
大阪大学 医学系研究科消化器内科学
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Tsuji S
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Tsuji Shingo
大阪大学 医学部 保健学科 病態生体情報学
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Funahashi Tohru
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine
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Fujisato Toshiya
Department Of Organ Transplantation Cardiovascular Surgery National Cardiovascular Center
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Tamura S
Osaka University
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Funahashi Tohru
Department Of Internal Medicine And Molecular Science Osaka University Graduate School Of Medicine
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Shimomura Iichiro
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University
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Kihara Shinji
Department Of Metabolic Medicine
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Kaibe Masaharu
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Ouchi Noriyuki
Boston University
-
Ouchi Noriyuki
Molecular Cardiology/whitaker Cardiovascular Institute Boston University School Of Medicine
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Ouchi Noriyuki
Molecular Cardiology / Whitaker Cardiovascular Institute Boston University School Of Medicine
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Tamura Shinji
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Osaka University Medical S
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Kiso S
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Osaka University
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Kiso Shinichi
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Osaka University Medical S
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Hayashi Naoaki
Division Of Medicine Institute Of Gastroenterology Tokyo Women's Medical University
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Hayashi Noriyuki
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Osaka University
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Hayashi Norio
Department Of Gastroenterology And Hepatology Osaka University Graduate School Of Medicine
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Shimomura Iichiro
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Kuroda Yohei
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Kobayashi Toru
Center for Adult Diseases
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Kikkawa Toshiro
Sumitomo Hospital
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Kihara Shinji
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Osaka University
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Matsuzawa Yuji
Department Of 2nd Internal Medicine Faculty Of Medicine Oaka University
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Kiso Shinichi
Department Of Metabolic Medicine Osaka University Graduate School Of Medicine
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Nagai Yoshiyuki
Department Of Cardiology Izumisano Municipal Hospital Rinku General Medical Center
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Okamoto Yoshihisa
Department Of Bioregulation Nippon Medical School
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Tamura Shinji
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Osaka University
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Hiuge Aki
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Nomura Kei
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Sonoda Mina
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Seki Kouichi
Department Of Internal Medicine Hyogo Prefectural Nishinomiya Hospital
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Yamasaki Masao
Department Of Cardiovascular Medicine The Graduate School Of Medicine The University Of Tokyo
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Nakagawa Yasuhiko
Department Of Cardiology Izumisano Municipal Hospital Rinku General Medical Center
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Kikuya Masahiro
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Arita Yukio
Division Of Cardiology Department Of Medicine Sumitomo Hospital
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Morikami Yasuhiro
Department Of Cardiology Japanese Red Cross Kumamoto Hospital
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Kihara Shinji
Department Of Metabolic Medicine Osaka University
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Fujita Koichi
Department Of Metabolic Medicine Graduate School Of Medicine
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Kubo Masaharu
Department Of Internal Medicine Sumitomo Hospital
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Koseki Masahiro
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Ouchi Noriyuki
Department Of Pediatrics Nagoya University Graduate School Of Medicine:developmental Pediatrics Nago
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Komura Noriyuki
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Hayashi Nobuhiko
Department Of Gastroenterology Osaka University
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Matsuzawa Yuuji
Department Of Cardiology Sumitomo Hospital
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Funahashi Tohru
Department Of Cardiovascular Surgery National Cerebral And Cardiovascular Center
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Fujita Koichi
Department Of Gastroenterology Yodogawa Christian Hospital
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Hayashi Noriyuki
Department Of Chemistry Faculty Of Science Toyama University
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Ohashi Naoki
Molecular Cardiology Boston University School Of Medicine
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Kawamoto Toshiharu
Department Of Cardiology National Hospital Organization Kure Medical Center
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Okada Takuya
Departmen Of Communications And Integrated Systems Tokyo Institute Of Technology
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Kaibe Masaharu
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Maeda Kazuhisa
Department Of Internal Medicine And Rehabilitation Science Tohoku University Graduate School Of Medi
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Sumitsuji Satoru
Departmane Of Cardiology Rinku General Hospital
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Fukunaga Takashi
熊本大学 医学教育部循環器病態学
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Kihara Shinji
Department Of Biomedical Informatics Graduate School Of Medicine Osaka University
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Tamba Sachiko
Department Of Endocrinology And Metabolism Sumitomo Hospital
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SONODA Mina
Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine
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