Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men
スポンサーリンク
概要
- 論文の詳細を見る
Objective Visceral fat accumulation is an underlying component of the metabolic syndrome (MetS). Hypoadiponectinemia is one of the key molecules of the MetS. In the present study, we investigated the relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men. Patients and Methods The study group comprised 1,520 Japanese employed men (mean age: 45.6±10.4 years, ± SD), who had undergone an annual health check-up both in 2004 and 2005. In addition to parameters measured in the annual health check-up, visceral fat area (VFA) and serum adiponectin concentration were measured by the bioelectrical impedance analysis method and a sandwich enzyme-linked immunosorbent assay (ELISA) system, respectively. Results Visceral fat accumulation was identified in 56.1% of the subjects with hyperuricemia. There was significant positive correlation between visceral fat area and serum uric acid levels (r=0.223, p<0.0001), and negative correlation between serum adiponectin concentration and serum uric acid levels (r=-0.198, p<0.0001). The one-year change in VFA was associated with the one-year change in serum uric acid levels. Stepwise multiple regression analysis showed that VFA and the serum adiponectin concentration were significant explanatory variables for serum uric acid levels. Conclusion Hyperuricemia is significantly associated with visceral fat accumulation and hypoadiponectinemia in Japanese men.
- 社団法人 日本内科学会の論文
著者
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MATSUZAWA Yuji
Sumitomo Hospital
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Shimomura Iichiro
Department of Metabolic Medicine, Osaka University Graduate School of Medicine
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NAKAMURA Tadashi
Department of Metabolic Medicine, Osaka University Graduate School of Medicine
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Kihara Shinji
Department of Metabolic Medicine, Osaka University
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Fujita Koichi
Department of Metabolic Medicine, Graduate School of Medicine
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Funahashi Tohru
Department of Metabolic Medicine, Graduate School of Medicine
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Nishizawa Hitoshi
Department of Internal Medicine and Molecular Science, Graduate School Of Medicine, Osaka University
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Kihara Shinji
Department Of Metabolic Medicine Osaka University Graduate School Of Medicine
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Matsuzawa Y
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Tamba Sachiko
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Okauchi Yukiyoshi
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Ogawa Tomoko
Amagasaki City Office, General Affairs Bureau, Personal Department, Payroll Section, Employee Health
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Noguchi Midori
Amagasaki City Office, General Affairs Bureau, Personal Department, Payroll Section, Employee Health
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Ryo Miwa
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Iwahashi Hiromi
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Yamagata Kazuya
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Yamagata Kazuya
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University
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Ryo Miwa
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University
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Okauchi Yukiyoshi
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
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Shimomura Iichiro
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University
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Nishizawa Hitoshi
Department Of Cardiology National Hospital Organization Kure Medical Center
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Funahashi Tohru
Department Of Cardiovascular Surgery National Cerebral And Cardiovascular Center
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Fujita Koichi
Department Of Gastroenterology Yodogawa Christian Hospital
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Nakamura Tadashi
Department Of Anesthesia Junwakai Memorial Hospital
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Iwahashi Hiromi
Department Of Gastroenterology And Hepatology Osaka University Graduate School Of Medicine
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Kihara Shinji
Department Of Biomedical Informatics Graduate School Of Medicine Osaka University
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Tamba Sachiko
Department Of Endocrinology And Metabolism Sumitomo Hospital
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Funahashi Tohru
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Noguchi Midori
Amagasaki City Office, Environment & Civic Affairs Bureau Health Support Promotion Section, Japan
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