Synthesis and Immunoadjuvant Activity of Acylamino Analogs of N-Acetylmuramoyl-L-alanyl-D-isoglutamine

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概要

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• A variety of long-chain fatty acylamino analogs of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP), such as N-(acyl)muramoyl-dipeptides (1) and N-acetyl-6-(acylamino)-6-deoxymuramoyl-dipeptides (2), were synthesized to examine their immunological activities. All the N-(acyl)muramoyl-L-alanyl-D-isoglutamines (1) were active as adjuvant on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs. N-(3-Hydroxy-2-tetradecyloctadecanoylamino)muramoyl-L-alanyl-D-isoglutamine (1d) and N-acetyl-6-deoxy-6-(3-hydroxy-2-docosylhexacosanoylamino)murarnoyl-L-alanyl-, -L-valyl-, and -L-seryl-D-isoglutamines (2) showed antitumor activity by suppressing tumor (Meth-A fibrosarcoma) growth in syngeneic BALB/c mice.

• 社団法人 日本農芸化学会の論文

著者

• Azuma Ichiro

  Institute Of Immunological Cience

• Hasegawa Akira

  Departmemt Of Information And Imaging Sciences Faculty Of Engineering Chiba University

• Kiso Makoto

  Department Of Applied And Bio-organic Chemistry Gifu University

• OKUMURA Hiroyuki

  Institute of Immunological Science, Hokkaido University

• KAMISANGO Kei-ichi

  Institute of Immunological Science, Hokkaido University

• SAKI Ikuo

  Institute of Immunological Science, Hokkaido University

• TANIO Yoshiro

  Institute of Immunological Science, Hokkaido University

• YAMAMURA Yuichi

  Osaka University

• KISO Makoto

  Department of Agricultural Chemistry, Gifu University

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