Blood Flow Redistribution During Exercise Contributes to Exercise Tolerance in Patients With Chronic Heart Failure

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概要

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• Background It is widely known that blood flow redistribution is impaired in patients with chronic heart failure (CHF). However, the relationship between exercise tolerance and the degree of blood flow redistribution is not fully understood. Whole-body thallium-201 chloride (^<201>T1) scintigraphy can estimate blood flow distribution. This study will evaluate the relationship between exercise tolerance and blood flow redistribution using whole-body scintigraphy in patients with CHF. Methods and Results Exercise stress whole-body thallium scintigraphy was performed in 19 patients with CHF (mean ejection fraction: 33.0%; peak oxygen uptake: IS.Sml-mhn^<-1>・kg^<-1>). Blood flow redistribution was quantified by comparing the regional thallium count (count/pixel) in the thigh and arm. We then assessed the relationship between these parameters and parameters obtained from cardiopulmonary exercise testing. 201 Thallium-chloride uptake in the thigh increased during exercise compared to rest (p<0.05), while its uptake in the arm was not dif- ferent between exercise and rest. Increased ^<201>T1 uptake in the thigh during exercise was positively correlated with exercise tolerance (r=0.689). In contrast, ^<201>T1 uptake in the arm was not correlated with exercise tolerance. Conclusions By using this method, it is concluded that blood flow redistribution to the exercising muscle increases as the exercise tolerance increases in patients with CHF.

• 社団法人日本循環器学会の論文
• 2007-03-20

著者

• HASEGAWA Akira

  Department of Quantum Science and Energy Engineering, Tohoku University

• Kurabayashi Masahiko

  Department of Medicine and Biological Science, Gunma University Graduate School of Medicine

• Oshima Shigeru

  Gunma Prefectural Cardiovascular Center

• Taniguchi K

  Division Of Cardiology Gunma Prefectural Cardiovascular Center

• Adachi Hitoshi

  Gunma Prefectural Cardiovascular Center

• Taniguchi Koichi

  Gunma Prefectural Cardiovascular Center

• Miyazaki Akihisa

  Department of Cardiology, Gunma Prefectural Cardiovascular Center

• Adachi H

  Department Of Cardiology Gunma Prefectural Cardiovascular Center

• Adachi Hitoshi

  群馬大学 医学系研究科臓器病態内科学

• Hasegawa Akira

  群馬大学 医学系研究科臓器病態内科学

• Hasegawa Akira

  Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine

• Miyazaki Akihisa

  Department Of Medicine And Biological Science Graduate School Of Medicine Gunma University

• Adachi Hitoshi

  Gunma Prefecture Cardiovascular Center

• Kurabayashi Masahiko

  Department Of Cardiovascular Medicine Gunma University School Of Medicine

• Ohshima Shigeru

  Gunma Prefectural Cardiovascular Center

• Hasegawa Akira

  Department Of Applied Bioorganic Chemistry Gifu University

• Hasegawa Akira

  Department Of Medicine And Biological Science Graduate School Of Medicine Gunma University

• Kuro-o Makoto

  東京大学 第3内科

• Miyajima Akito

  Second Department Of Internal Medicine Gunma University School Of Medicine

• Kurabayashi Masahiko

  Department Of Cardiology Kanazawa Medical University

• Taniguchi Koichi

  The Gunma Prefectural Cardiovascular Center Maebashi Gunma University School Of Medicine

• Hasegawa Akira

  Departmemt Of Information And Imaging Sciences Faculty Of Engineering Chiba University

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