Synthesis of lipophilic muramyl dipeptide derivatives via O-aminoacyl intermediates.
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概要
- 論文の詳細を見る
Incorporation of an amino acid into the 6 position of the muramic acid moiety of muramyl dipeptide has been achieved, providing an effective means for the synthesis of various new derivatives. Six new muramyl dipeptide derivatives with an <I>N</I>-acylated amino acid were synthesized using these intermediates and their immunological activity was examined. All the derivatives exhibited adjuvant activity on the induction of delayed-type hypersensitivity to <I>N</I>-acetyl-3-(4-arsonophenylazo)-L-tyrosine.
- 公益社団法人 日本化学会の論文
著者
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Fujino Masahiko
Central Research Division Takeda Chemical Ind. Ltd.
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Azuma Ichiro
Institute Of Immunological Cience
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YAMAMURA YUICHI
The Third Department of Internal Medicine, Medical School of Osaka University
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Fukuda Tsunehiko
Central Research Division, Takeda Chemical Industries, Ltd.
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Kobayashi Shigeru
Central Research Division, Takeda Chemical Industries, Ltd.
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Yukimasa Hidefumi
Central Research Division, Takeda Chemical Industries, Ltd.
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Imada Isuke
Central Research Division, Takeda Chemical Industries, Ltd.
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